Chapter title |
Pharmacologically Targeting the WNT/β-Catenin Signaling Cascade: Avoiding the Sword of Damocles.
|
---|---|
Book title |
Pharmacology of the WNT Signaling System
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Published in |
Handbook of experimental pharmacology, September 2021
|
DOI | 10.1007/164_2021_523 |
Pubmed ID | |
Book ISBNs |
978-3-03-085498-0, 978-3-03-085499-7
|
Authors |
Lai, Keane K Y, Kahn, Michael, Lai, Keane K. Y. |
Abstract |
WNT/β-catenin signaling plays fundamental roles in numerous developmental processes and in adult tissue homeostasis and repair after injury, by controlling cellular self-renewal, activation, division, differentiation, movement, genetic stability, and apoptosis. As such, it comes as no surprise that dysregulation of WNT/β-catenin signaling is associated with various diseases, including cancer, fibrosis, neurodegeneration, etc. Although multiple agents that specifically target the WNT/β-catenin signaling pathway have been studied preclinically and a number have entered clinical trials, none has been approved by the FDA to date. In this chapter, we provide our insights as to the reason(s) it has been so difficult to safely pharmacologically target the WNT/β-catenin signaling pathway and discuss the significant efforts undertaken towards this goal. |
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