Clinical, Biological and Molecular Aspects of COVID-19

Jafari-Oori, Mehdi, Ghasemifard, Fatemeh, Ebadi, Abbas, Karimi, Leila, Rahimi-Bashar, Farshid, Jamialahmadi, Tannaz, Guest, Paul C, Vahedian-Azimi, Amir, Sahebkar, Amirhossein, Mehdi Jafari-Oori, Fatemeh Ghasemifard, Abbas Ebadi, Leila Karimi, Farshid Rahimi-Bashar, Tannaz Jamialahmadi, Paul C. Guest, Amir Vahedian-Azimi, Amirhossein Sahebkar, Guest, Paul C.

Acute respiratory distress syndrome (ARDS) is a fatal complication of the new severe acute respiratory syndrome coronavirus (SARS-CoV-2), which causes COVID-19 disease. This scoping review was carried out with international, peer-reviewed research studies and gray literature published up to July 2020 in Persian and English languages. Using keywords derived from MESH, databases including Magiran, IranMedex, SID, Web of Sciences, PubMed, Embase via Ovid, Science Direct, and Google Scholar were searched. After screening titles and abstracts, the full texts of selected articles were evaluated, and those which passed the criteria were analyzed and synthesized with inductive thematic analysis. Study quality was also evaluated using a standard tool. The overall prevalence of ARDS was estimated using a random-effects model. This led to identification of 23 primary studies involving 2880 COVID-19 patients. All articles were observational with a cross-sectional, retrospective, case report, and cohort design with moderate to strong quality. The main findings showed that COVID-19-related ARDS has a high prevalence and is different to ARDS due to other etiologies. Elderly and patients with comorbidities and organ failure should be closely surveyed for respiratory organ indications for several weeks after the onset of respiratory symptoms. There is currently no definitive treatment for ARDS in COVID-19 disease, and supportive therapies and their effects are somewhat controversial.