Drug Addiction

Table of Contents

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   Book Overview
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   Chapter 1 DARPP-32 Mediates the Actions of Multiple Drugs of Abuse
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   Chapter 2 Drug Discovery From Natural Sources
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   Chapter 3 Computational Methods in Drug Design: Modeling G Protein-Coupled Receptor Monomers, Dimers, and Oligomers
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   Chapter 4 Symbiotic Relationship of Pharmacogenetics and Drugs of Abuse
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   Chapter 5 Monoclonal Antibody Form and Function: Manufacturing the Right Antibodies for Treating Drug Abuse
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   Chapter 6 Cocaine- and Amphetamine-Regulated Transcript Peptides Play a Role in Drug Abuse and Are Potential Therapeutic Targets
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   Chapter 7 RNAi-Directed Inhibition of DC-SIGN by Dendritic Cells: Prospects for HIV-1 Therapy
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   Chapter 8 Viewing Chemokines as a Third Major System of Communication in the Brain
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    Chapter 9 Targeting the PDZ Domains of Molecular Scaffolds of Transmembrane Ion Channels
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    Chapter 10 Neuronal Nicotinic Acetylcholine Receptor Expression and Function on Nonneuronal Cells
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    Chapter 11 Role of Monoamine Transporters in Mediating Psychostimulant Effects
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    Chapter 12 Development of the Dopamine Transporter Selective RTI-336 as a Pharmacotherapy for Cocaine Abuse
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    Chapter 13 Serotonin Transporters: Implications for Antidepressant Drug Development
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    Chapter 14 Recent Advances for the Treatment of Cocaine Abuse: Central Nervous System Immunopharmacotherapy
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    Chapter 15 κ Opioids as Potential Treatments for Stimulant Dependence
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    Chapter 16 Regulation of Monoamine Transporters: Influence of Psychostimulants and Therapeutic Antidepressants
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    Chapter 17 Hallucinogen Actions on 5-HT Receptors Reveal Distinct Mechanisms of Activation and Signaling by G Protein-Coupled Receptors
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    Chapter 18 Recognition of Psychostimulants, Antidepressants, and Other Inhibitors of Synaptic Neurotransmitter Uptake by the Plasma Membrane Monoamine Transporters
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    Chapter 19 Dual Dopamine/Serotonin Releasers as Potential Medications for Stimulant and Alcohol Addictions
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    Chapter 20 Receptors of Mammalian Trace Amines
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    Chapter 21 The Role of Crystallography in Drug Design
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    Chapter 22 Opioid Peptide-Derived Analgesics
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    Chapter 23 Opioid Ligands with Mixed μ/δ Opioid Receptor Interactions: An Emerging Approach to Novel Analgesics
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    Chapter 24 Small-Molecule Agonists and Antagonists of the Opioid Receptor-Like Receptor (ORL1, NOP): Ligand-Based Analysis of Structural Factors Influencing Intrinsic Activity at NOP
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    Chapter 25 Kappa Opioid Antagonists: Past Successes and Future Prospects
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    Chapter 26 In Vitro and Direct In Vivo Testing of Mixture-Based Combinatorial Libraries for the Identification of Highly Active and Specific Opiate Ligands
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    Chapter 27 Current Status of Immunologic Approaches to Treating Tobacco Dependence: Vaccines and Nicotine-Specific Antibodies
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    Chapter 28 New Paradigms and Tools in Drug Design for Pain and Addiction
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    Chapter 29 Neuropeptide-Processing Enzymes: Applications for Drug Discovery
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    Chapter 30 CNS Drug Delivery: Opioid Peptides and the Blood-Brain Barrier
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    Chapter 31 Cell-Permeable, Mitochondrial-Targeted, Peptide Antioxidants
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    Chapter 32 Targeting Opioid Receptor Heterodimers: Strategies for Screening and Drug Development
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    Chapter 33 Homology Modeling of Opioid Receptor-Ligand Complexes Using Experimental Constraints
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    Chapter 34 Molecular Recognition of Opioid Receptor Ligands
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    Chapter 35 Role of Morphine’s Metabolites in Analgesia: Concepts and Controversies
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    Chapter 36 Mu Opioid Receptor Regulation and Opiate Responsiveness
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    Chapter 37 Agmatine: Biological Role and Therapeutic Potentials in Morphine Analgesia and Dependence
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    Chapter 38 The Therapeutic Potential of Drugs that Target Cannabinoid Receptors or Modulate the Tissue Levels or Actions of Endocannabinoids
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    Chapter 39 Further Advances in the Synthesis of Endocannabinoid-Related Ligands
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    Chapter 40 Ajulemic Acid (IP-751): Synthesis, Proof of Principle, Toxicity Studies, and Clinical Trials
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    Chapter 41 Conformational Characteristics of the Interaction of SR141716A with the CB1 Cannabinoid Receptor as Determined Through the Use of Conformationally Constrained Analogs
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    Chapter 42 Activation of G-Proteins in Brain by Endogenous and Exogenous Cannabinoids
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    Chapter 43 2-Arachidonoylglycerol (2-AG) Membrane Transport: History and Outlook
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    Chapter 44 Endocannabinoid Mechanisms of Pain Modulation