Chapter title |
Immunoproteasome-specific inhibitors and their application.
|
---|---|
Chapter number | 27 |
Book title |
Ubiquitin Family Modifiers and the Proteasome
|
Published in |
Methods in molecular biology, January 2012
|
DOI | 10.1007/978-1-61779-474-2_27 |
Pubmed ID | |
Book ISBNs |
978-1-61779-473-5, 978-1-61779-474-2
|
Authors |
Basler M, Groettrup M, Michael Basler, Marcus Groettrup |
Editors |
R. Jürgen Dohmen, Martin Scheffner |
Abstract |
Immunoproteasomes (IPs) containing the interferon-inducible subunits β1i (LMP2), β2i (MECL-1), and β5i (LMP7) alter proteasomal cleavage preference, optimise the generation of peptide ligands of MHC class I molecules, alter cytokine profile, influence T-helper cell differentiation, and play a role in T-cell survival. Small molecule inhibitors are useful tools for probing the role of the immunoproteasome in immune functions. Here, we describe different methods to characterise immunoproteasome-selective inhibitors. Thereby, we provide the methodology to analyse the specificity and cell permeability of immunoproteasome inhibitors, as well as to functionally investigate immunoproteasome inhibitors in antigen presentation. |
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