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Animal Cell Technology Meets Genomics

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Cover of 'Animal Cell Technology Meets Genomics'

Table of Contents

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    Book Overview
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    Chapter 1 Effect of Osmotic Pressure on Gs-Ns0 Expression System
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    Chapter 2 Molecular Approaches to Influence Epigenetic Effectors of Transient and Stable Transgene Expression in Mammalian Cells
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    Chapter 3 Genomic Exploration on Chinese Hamster Ovary Cells
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    Chapter 4 Roles for Glycosylation in Receptor-Ligand Interactions in the Immune System
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    Chapter 5 Investigations on Mannose-6-Phosphate Receptor Mediated Protein Uptake
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    Chapter 6 Analysis of Multiple Apoptosis Parameters Using a Microfluidic Chip-Based System
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    Chapter 7 Inhibiting Apoptosis in Cell Culture Using Multiple Inhibitors
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    Chapter 8 Pausing of Mammalian Cells by Cold Exposure, Limits and Opportunities
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    Chapter 9 The Functional Competence of Animal Cells: Anal Ysis of the Secretory Pathway
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    Chapter 10 Proteome Analysis of Recombinant CHO Cells Under Hyperosmotic Stress
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    Chapter 11 Expression Profiling Analysis of Sodium Butyrate-Induced Chinese Hamster Ovary Cells in Defined Medium
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    Chapter 12 Intracellular Nucleotide Pools for Optimizing Product-Oriented Transient Transfection of Hek293 Cells in Suspension
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    Chapter 13 Impact of Yeast Pyruvate Carboxylase on the Productivity of Animal Host Cell Lines
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    Chapter 14 Environmental Effects of Lactate on High-Five™ Insect Cell Metabolism
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    Chapter 15 Correlation of Intracellular Nucleotide Pools to Amino Acid Concentrations in Culture Media by the Application of Multivariate Methods
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    Chapter 16 Engineering Trichoplusia ni (High-Five™) Insect Cells to Express a Cytosolic Pyruvate Carboxylase Enzyme Improves the Viability of the Cells in Batch, Fed-Batch and Perfusion Cultures
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    Chapter 17 Insect Cell Culture Medium Selection and Optimisation Based on Monitoring and Economical Considerations
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    Chapter 18 Antiapoptotic Activity of Synthetic and Nnatural Peptides
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    Chapter 19 Effect of Antiapoptotic Genes Expression on Cell Growth and Monoclonal Antibody Productivity in a Hybridoma Cell Line
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    Chapter 20 Amplified Dicistronic Expression Units Mediate Apoptosis Protection in CHO-DG44 Cells Adapted for Growth in Serum-Free Media, Impact on Mitochondria Copy Number
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    Chapter 21 Effect of Reduced Water on the Apoptotic Cell Death Triggered by Oxidative Stress in Pancreatic β HIT-T15 Cell
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    Chapter 22 Characterization of Apoptosis in a CHO Cell Line Cultivated in Batch and Continuous Culture: Effect of Medium, Specific Perfusion Rate and Chemical Inhibitors
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    Chapter 23 Hydrogen Peroxide-Induced Cellular Senescence is Regulated via Two Different Pathways
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    Chapter 24 Identification of Autocrine Factors Influencing Proliferation in Serum-Free Cultures of Trichoplusia NI Cells
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    Chapter 25 The Effects of Insulin and Long™R3IGF-I on Chinese Hamster Ovary Cells: Cell Survival, Receptor Activation and Second Messenger Pathways
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    Chapter 26 Conditioned Medium Factors in Protein-Free Cultures of NS0 Cells
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    Chapter 27 Production of Human Anti-Peptide Antibody for Clinical Use by In Vitro Immunization
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    Chapter 28 Optimization of in Vitro Immunization Protocol to Produce Antigen Specific Human Monoclonal Antibody by Demonstrating the Role of IL-10
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    Chapter 29 Eextracellular Histone H4 from SF9 Cells Is Antimicrobial
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    Chapter 30 Analyzing Calcium Phosphate Transfection of Adherent CHO Cells Using Microscopic Live Imaging
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    Chapter 31 Effects of Multiplicity of Infection (MOI) and Cell Cycle on Baculovirus Infection Kinetics
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    Chapter 32 Non-Freezing Preservation and Subsequent Recovery of Hepatocytes Under PO2- and pH-Controlled Conditions for Continuous Supply of Cells for Bioartificial Liver Support
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    Chapter 33 Selection of MDCK Subclones with Various Genotypic and Phenotypic Markers: Sensitivity to Influenza Virus Infection
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    Chapter 34 Extracellular Metalloproteases and Their Inhibitors Expressed by The IFN-γ Producing CHO-320 Cell Line
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    Chapter 35 Novel Small-Molecule AKT1 Inhibitors Discovered by Redistribution™-Based High- Throughput Screening
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    Chapter 36 Influence of Mistletoe Extracts and Its Components on in Vitro Physiology of Cancer Cells
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    Chapter 37 Rapid in-Process Monitoring of Antibody Integrity, Purity and Titre- 2100 Bioanalyser (Lab on a Chip) Study
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    Chapter 38 Toxicological Evaluation of Haine River Waste-Water Samples to Appropriately Sensitized Cultured Fathead Minnow Cells Compared With the Microtox® Method
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    Chapter 39 3D-Cultivation and Characterisation of Osteogenic Cells for the Production of Highly Viable Bone Tissue Implants
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    Chapter 40 Carbon Source Has a Considerable Influence on Extracellular Matrix Formation, Demonstrated on Specific Collagen Expression of Primary Human Tenocytes
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    Chapter 41 Design and Characterization of Cardiomyocyte-Derived Microtissues
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    Chapter 42 Process Development for Standardized Generation of Monocyte-Derived Dendritic Cells: Applicability in Breast Cancer Immunotherapy
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    Chapter 43 Stemline™ Hematopoietic Stem Cell Expansion Medium, a Serum-Free Medium for the Expansion of CD34+ Hematopoietic Stem Cells and Progenitors
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    Chapter 44 Mesenchymal Stem Cells: A Very First Step Towards Large Scale Cell Culture Strategies
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    Chapter 45 Expansion of Murine Embryonic Stem Cells on Microcarriers-Functional Characteristics and Scale-Up Potential
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    Chapter 46 In Vitro Cultivation of Rabbit Mesenchymal Stromal Cells on 3D Bioresorbable Calcium Phosphate Scaffolds for the Generation of Bone Tissue Implants
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    Chapter 47 Establishment and Characterization of Human Medullary Thyroid Carcinoma Cell Lines for Immunotherapy
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    Chapter 48 Suppression of Cell Growth by Platinum Nanocolloids as Scavengers against Reactive Oxygen Species
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    Chapter 49 Comparison of Fluidized Bed and Fed Batch Reactor Cultures for Production of Anti-HIV-Antibody
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    Chapter 50 Suppression of Oxidative Stress-Induced Apoptosis of Neuronal Cells by Electrolyzed-Reduced Water
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    Chapter 51 Spheroid Formation by Encapsulation of Cancer Cells to Mimic Small Size Tumors
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    Chapter 52 Bioreactor for Continuous Biomechanical Characterization of Cellular Systems and Tissue-Engineered Biohybrid Tissues
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    Chapter 53 Membrane-Separated Cocultivation of Cord Blood Hematopoietic Stem Cells with Stromal Cell Lines
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    Chapter 54 Anti-Apoptotic Genes Protect an Insulinoma Cell Line From Cell Death Induced by Hypergl Ycemia
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    Chapter 55 Preparation and Characterization of an Idiotype-Dendritic Cell Vaccing for Immunotherapy of Multiple Myeloma
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    Chapter 56 Pretreatment with Polycations Enhances Adenoviral Infection Levels in Serum-Free PER.C6⊆ Cells as Well as Hek 293 Cells
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    Chapter 57 Optimizing the Production of Cardiomyocytes from Mouse Embryonic Stem Cells in a 2L Stirred Tank Reactor
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    Chapter 58 Establishment and Characterization of CD4+ Killer-T-Cells (KTCS) a Promising New Tool for Adoptive Immunotherapy
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    Chapter 59 Successful Development of a Robust Adenovirus Production Process Primarily Relies on a Better Understanding of Packaging Cell Line Physiology and Vector Replication Kinetics
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    Chapter 60 Retroviral Vector Stability: Inactivation Kinetics and Membrane Properties
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    Chapter 61 Comparison of Host Cell Lines and Production Methods for a New Generation of Oncolytic Adenoviral Vectors
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    Chapter 62 Process Development for a Veterinary Vaccine against Heartwater
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    Chapter 63 A New Method for the Quantitative Determination of Enveloped Viral Particles
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    Chapter 64 Development of a 293T Cell Line for the Production of Virus Like Particles in Bioreactors
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    Chapter 65 Effect of MOI and Medium Composition on Adenovirus Infection Kinetics
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    Chapter 66 Ion-Exchange Chromatography Based Strategies for Purification of Viral Vectors
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    Chapter 67 Scaling up of Endothelial Cells Culture for the Production of a Rickettsiae Vaccine: Valuation of the Importance of the Interference Effects
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    Chapter 68 Inducible Gene Expression for Antibiotic Drug Discovery and Diagnostics
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    Chapter 69 Nucleic Acid Capture Assay: A Novel High- Throuhgput Method for Direct Mrna Quantitation
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    Chapter 70 High Throughput Transient Transfections of Hek293Ebna Cells — Devel Opment of an Integrated Expression Purification Process at 100 ml Scale
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    Chapter 71 Transient Gene Expression in Suspension Hek293 Cells: Application to Large-Scale Protein Production
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    Chapter 72 Monoclonal Antibody Production: Determination of Appropriate System and Medium for Production Enhancement and Decrease of Overall Production Time
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    Chapter 73 The Secrets of Transfection in Serumfree Suspension Culture
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    Chapter 74 From Genes to Proteins: Full Open Reading Frame (ORF) Clones and Their Application in Functional Research
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    Chapter 75 A Versatile Disposable Culture System for High Throughput Screening of Process Parameters and Production Cell Lines
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    Chapter 76 Long Time Storage of Pre-Inoculated Multi-Well PLlates for Cell-Based Assay Kits Used for Drug Iedntification and Characterisation
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    Chapter 77 Comparative Secretion Levels of Recombinant Proteins between Insect Cell-Bbaculovirus and Mammalian Hek293EBNA Cells
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    Chapter 78 Microfluidic Technology Applied to Protein Sizing and Quantitation
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    Chapter 79 Cryostock a Software for Cell Culture Management
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    Chapter 80 Targeting the Human Immunoglobulin Loci for High Level Hgene
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    Chapter 81 Mar Elements as Tools to Increase Protein Production by CHO Cells
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    Chapter 82 Cell Line Engineering for Production of Therapeutic Antibody Glycoforms with Increased Biological Activity
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    Chapter 83 Development of a Metabolically Optimized Fermentation Process Based on Glucose-Limited CHO Perfusion Culture
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    Chapter 84 Applications of Quasi Real-Time Metabolic Flux Analysis in Mammalian Cell Culture Process Development
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    Chapter 85 Data-Based Modelling of Cell Cultures
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    Chapter 86 Cell Culture and Downstream Processing Integration Using Proteinchip® Technology Application to Protein Analysis and Purification in Biopharmaceutical Manufacturing
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    Chapter 87 The Prospects for Insect Cells for Use as a Cell Substrate for the Production of Biotherapeutics
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    Chapter 88 High Performance Cell Culture Platform Technology for MAb Production
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    Chapter 89 Development and Integration of a New Animal-Component-Free Process for the Production of UK-279,276
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    Chapter 90 Towards an Affinity-Based Capture System for the Isolation of High Expression Cells Using a Co-Expressed Surface Protein
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    Chapter 91 Effect of Doxycycline-Regulated Calnexin and Calreticulin Expression on Specific Thrombopoietin Productivity of Recombinant CHO Cells
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    Chapter 92 Recombinant Glycoprotein Expression Development of a Homologous CHO Expression System
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    Chapter 93 Generation of Recombinant Antibody Manufacturing Cell Lines Using Cell-Cell Fusion
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    Chapter 94 Cloning and Expression of Biopharmaceuticals in CHO.K1 and BHK-21 Cells
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    Chapter 95 Camel Single-Domain Antibodies as Modular Building Blocks to Make Bivalent Constructs for Use in Immunotherapy of Cancer
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    Chapter 96 Establishment of Efficient Cloning Method for Variable Region Genes of Antigen Specific Human Monoclonal Antibody
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    Chapter 97 From Gene to Monoclonal Antibody: Efficient Screening by Cell Sorting
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    Chapter 98 Development of an Integrated Strategy for Recombinant Cell Line Selection
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    Chapter 99 Gene Transfer to a Animal Cells in Culture by Microinjection: A Novel Tool to Create Recombinant Cell Lines?
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    Chapter 100 Evaluation of the Stability of NS0 Cell Lines Expressing Recombinant Human IgG
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    Chapter 101 High Throughput Screening and Selection of Single Cells in Suspension Using Fluorescence Parameters
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    Chapter 102 Control of Key Parameters in the Development of Mammalian Production Clones
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    Chapter 103 Establishment of Screening Systems for Recombinant Cell Lines: Early Prediction of the Suitability as a Production Clone
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    Chapter 104 Characterisation of CHO Subclones Showing Profound Changes in Performance When Propagated in Different Cultivation Systems
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    Chapter 105 High Level Production of Recombinant IgG in the Human Cell Line PER.C6™
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    Chapter 106 Creating a New Medium to Help Meet the Variable Nutritional Requirements of Chinese Hamster Ovary (CHO) Cell Clones
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    Chapter 107 Development of an Efficient Medium Optimization Kit for Factorial Matrix Design—A Statistical Approach to Increase Cell Growth and Productivity of Recombinany CHO Cells
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    Chapter 108 An Efficient Approach to Cell Culture Medium Optimization — A Statistical Method to Medium Mixing
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    Chapter 109 Virus Inactivation in Foetal Calf Serum by a Combined Treatment of Gammairradiation and UV-C Irradiation
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    Chapter 110 Advances in Media Optimization: Two Automated Approaches that Increase Expression While Reducing Development Time
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    Chapter 111 The Importance of Cholesterol for Insect Cell Growth and Baculovirus Production
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    Chapter 112 Use of Rapeseed Proteins and Peptides as Supplements in Insect Cell Cultures
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    Chapter 113 Nutritional Performance of Wheat-Gluten-Derived Protein Hydrolysates in Hybridoma Cell Cultures. A Nutritional Function Study
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    Chapter 114 Synthechol™ Ynthetic Cholesterol for Cholesterol Dependent Cell Culture — Development of Non-Animal Derived Chemically Defined NS0 Medium
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    Chapter 115 NS0 Derivatives: MAB Production in Largescale SFM Formats
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    Chapter 116 Silk Protein Sericin Accelerates Proliferation of Various Mammalian Cells
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    Chapter 117 Image Analysis Based Real Time-Control of Glucose Concentration
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    Chapter 118 Online Analysis of Microcarrier Cultivations
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    Chapter 119 Error Analysis during Estimation of Metabolic Fluxes through Metabolite Balancing
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    Chapter 120 Generalized Logistic Equation Modeling of Mammalian Cell Batch Cultures
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    Chapter 121 In-Situ Microscopy Based Monitoring of Mammalian Cell Culture Processes
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    Chapter 122 A Noel Disposable Microtube for Rapid Assessment of Biomass in Cell Cultures
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    Chapter 123 Intracellular Monitoring of Baculovirus Infection of SF9 Insect Cells and R-Protein Production Using Anti-Alpha-1,3/4 Fucosyl Transferase Antibodies and Flow Cytometry
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    Chapter 124 Effect of Glucose and Glutamine Concentration on Metabolism of Animal Cells in Chemostat Culture
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    Chapter 125 Evaluation of a Novel apacitance Probe for On-Line Monitoring of Viable Cell Densities in Batch and Fed-Batch Animal Cell Culture Processes
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    Chapter 126 Sodium Butyrate Enhancement of Protein Expression in Hela Cells: Follow-Up of a Chimeric Reporter Gene Behaviour for Process Development
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    Chapter 127 Scalable, Serum-Free, High Efficiency Transfection of CHO Cells Using an Economical DNA Transfer Vehicle
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    Chapter 128 Process Optimization for an NS0-Derived Hybridoma Cell Line in a Chemically Defined, Protein-Free Medium
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    Chapter 129 Impact of Change in Fermentation Process pH and Dissolved Carbon Dioxide Concentration on Secreted Antibody Structure and Cell Physiology of a GS-NS0 Cell Line Expressing a Human Antibody
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    Chapter 130 Experimental Factorial Design for the Study of Some Variables in Roller Bottles Cell Culture
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    Chapter 131 Evaluation of Rollercell System for High Scale Production of Biopharmaceuticals
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    Chapter 132 Strategies for the Process Development of Monoclonal Antonpdoes for Therapeutic Use
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    Chapter 133 Optimisation of PEI-Mediated Transient Expression in Chinese Hamster Ovary Cells
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    Chapter 134 Development of Fed-Batch Process Producing Monoclonal Antibodies Using In-House Media
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    Chapter 135 Production of an Anti β2 Integrin Monoclonal Antibody by a Hybridoma Cell Line Grown in a 2 Liter Bioreactor
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    Chapter 136 Economic Evaluation of Disposables vs Stainless Steel within a Modular Pilot Plant Facility — a Comparative Analysis
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    Chapter 137 CGMP Manufacturing of a Fusion Protein in Mammalian Cells Using a Large-Scale Acoustic Perfusion System
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    Chapter 138 Influence of Culture Parameters on Viability in Perfusion Process
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    Chapter 139 Use of Hydrocyclone as an Efficient Tool for Cell Retention in Perfusion Cultures
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    Chapter 140 Effect of Different Variables on the Long-Term Spinfilter Clogging during Pilot-Scale Animal Cell Perfusion Runs
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    Chapter 141 Integrating Acoustic Perfusion in Mammalian Cell Culture: Temperature Control
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    Chapter 142 Flexible Fed-Batch Process Control of Animal Cells
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    Chapter 143 Development of a Fed-Batch Strategy for the Production of NS0-Derived Humanised Mab in Protein Free Medium
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    Chapter 144 Transfection to Manufacturing: Reducing Timelines for High Yielding GS-CHO Processes
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    Chapter 145 Optimization of a Fed-Batch Process Producing Humanized Antibodies
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    Chapter 146 Optimized Feeding Strategy for NS0 Cells
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    Chapter 147 Comparison of Complementary Interactions between Synthetic Ligands and t-PA by Hpmdc
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    Chapter 148 Effect of Nutrient Supplementation on the Biological Quality of tPA Produced by CHO Cells on Serum-Free Medium
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    Chapter 149 Modulation of the Glycosylation Repertoire of a Recombinant Human EPO Expressing Model Cell Line Under Different Culture Conditions
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    Chapter 150 Physicochemical Estimation of rhEPO Potency Produced in Suspension Culture
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    Chapter 151 Post-Translational Modification of Recombinant Human GM-CSF Expressed by Stable-Transfected CHO Cells under Different Culture Conditions
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    Chapter 152 Softmix, a new Scalable Mixing System for the Cultivation of Sensitive Cells on Microcarrier under Protein- Free Conditions
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    Chapter 153 Establishment of Fermentation Process for Hrepo Using Stirred Tank Fermenters in Perfusion Mode Using A Commercial Protein-Free Culture Medium
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    Chapter 154 Continuous Gmp Production in Hollow Fibre Bioreactors — Aviable Alternative for the Production of Low Volume Biopharmaceuticals
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    Chapter 155 Optimizing Cultivation Strategies in Different Scales of Hollow Fiber Bioreactors
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    Chapter 156 Increasing Antibody Production from Hollow Fiber Systems
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    Chapter 157 Production of Poliovirus, Rubella Virus, Measles Virus and Recombinant Adenovirus in Protein-Free Media
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    Chapter 158 Serum-Free Production of Poliovirus: A Comparative Study Using Microcarriers, Roller Bottles and Stationary Cell Culture
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    Chapter 159 Glutamine-Free Media for Vaccine Production Processes
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    Chapter 160 Serum Free Cultivation of Primary Chicken Embryo Fibroblasts in Microcarrier Systems for Vaccine Production
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    Chapter 161 Design of an Animal Protein Free Medium to Sustain Vero Cells Growth in a Stirred Tank Bioreactor
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    Chapter 162 Use of On-Line Our Measurements to Monitor and Improve Insect Cell Cultures for Recombinant Protein Production
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    Chapter 163 Production of Live Influenza Vaccine in MDCK Cell Line
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    Chapter 164 Elaboration of the Microencapsulated Forms of the Viral Vaccines
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    Chapter 165 HTS-Based Development of High-Producing CHO Cell Lines
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Title
Animal Cell Technology Meets Genomics
Published by
Springer Netherlands, January 2005
DOI 10.1007/1-4020-3103-3
ISBNs
978-1-4020-2791-8, 978-1-4020-3103-8
Editors

Francesc Gòdia, Martin Fussenegger

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The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Malaysia 1 2%
Switzerland 1 2%
Unknown 38 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 17%
Student > Ph. D. Student 6 15%
Other 2 5%
Professor 2 5%
Student > Master 2 5%
Other 2 5%
Unknown 20 49%
Readers by discipline Count As %
Agricultural and Biological Sciences 10 24%
Engineering 3 7%
Chemical Engineering 2 5%
Medicine and Dentistry 2 5%
Chemistry 2 5%
Other 1 2%
Unknown 21 51%