| Chapter title |
Differential Uptake of (68)Ga-DOTATOC and (68)Ga-DOTATATE in PET/CT of Gastroenteropancreatic Neuroendocrine Tumors.
|
|---|---|
| Chapter number | 18 |
| Book title |
Theranostics, Gallium-68, and Other Radionuclides
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2012
|
| DOI | 10.1007/978-3-642-27994-2_18 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-227993-5, 978-3-64-227994-2
|
| Authors |
Thorsten D. Poeppel, Ina Binse, Stephan Petersenn, Harald Lahner, Matthias Schott, Gerald Antoch, Wolfgang Brandau, Andreas Bockisch, Christian Boy, Poeppel, Thorsten D., Binse, Ina, Petersenn, Stephan, Lahner, Harald, Schott, Matthias, Antoch, Gerald, Brandau, Wolfgang, Bockisch, Andreas, Boy, Christian |
| Abstract |
Abundant expression of somatostatin receptors (sst) is a characteristic of neuroendocrine tumors (NET). Thus, radiolabeled somatostatin analogs have emerged as important tools for both in vivo diagnosis and therapy of NET. The two compounds most often used in functional imaging with positron emission tomography (PET) are (68)Ga-DOTATATE and (68)Ga-DOTATOC. Both analogs share a quite similar sst binding profile. However, the in vitro affinity of (68)Ga-DOTATATE in binding the sst subtype 2 (sst2) is approximately tenfold higher than that of (68)Ga-DOTATOC. This difference may affect their efficiency in detection of NET lesions, as sst2 is the predominant receptor subtype on gastroenteropancreatic NET. We thus compared the diagnostic value of PET/CT with both radiolabeled somatostatin analogs ((68)Ga-DOTATATE and (68)Ga-DOTATOC) in the same patients with gastroenteropancreatic NET. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 38 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 21% |
| Student > Ph. D. Student | 6 | 16% |
| Student > Bachelor | 5 | 13% |
| Student > Doctoral Student | 4 | 11% |
| Student > Master | 4 | 11% |
| Other | 6 | 16% |
| Unknown | 5 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 53% |
| Chemistry | 4 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 8% |
| Psychology | 2 | 5% |
| Immunology and Microbiology | 1 | 3% |
| Other | 2 | 5% |
| Unknown | 6 | 16% |