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Prospects for Chemoprevention of Colorectal Neoplasia

Overview of attention for book
Cover of 'Prospects for Chemoprevention of Colorectal Neoplasia'

Table of Contents

  1. Altmetric Badge
    Book Overview
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    Chapter 1 An Emerging Role for Anti-inflammatory Agents for Chemoprevention.
  3. Altmetric Badge
    Chapter 2 Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia.
  4. Altmetric Badge
    Chapter 3 Mode of Action of Aspirin as a Chemopreventive Agent
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    Chapter 4 Coxibs: Pharmacology, Toxicity and Efficacy in Cancer Clinical Trials
  6. Altmetric Badge
    Chapter 5 COX-2 Active Agents in the Chemoprevention of Colorectal Cancer
  7. Altmetric Badge
    Chapter 6 New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention.
  8. Altmetric Badge
    Chapter 7 Aspirin in Prevention of Sporadic Colorectal Cancer: Current Clinical Evidence and Overall Balance of Risks and Benefits
  9. Altmetric Badge
    Chapter 8 Nutritional Agents with Anti-lnflammatory Properties in Chemoprevention of Colorectal Neoplasia
  10. Altmetric Badge
    Chapter 9 Genetics, Inheritance and Strategies for Prevention in Populations at High Risk of Colorectal Cancer (CRC).
Attention for Chapter 2: Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia.
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Chapter title
Mechanistic Aspects of COX-2 Expression in Colorectal Neoplasia.
Chapter number 2
Book title
Prospects for Chemoprevention of Colorectal Neoplasia
Published in
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2012
DOI 10.1007/978-3-642-30331-9_2
Pubmed ID
22893198
Book ISBNs
978-3-64-230330-2, 978-3-64-230331-9
Authors

Dixon DA, Blanco FF, Bruno A, Patrignani P, Dan A. Dixon, Fernando F. Blanco, Annalisa Bruno, Paola Patrignani, Dixon, Dan A., Blanco, Fernando F., Bruno, Annalisa, Patrignani, Paola

Abstract

The cyclooxygenase-2 (COX-2) enzyme catalyzes the rate-limiting step of prostaglandin formation in pathogenic states and a large amount of evidence has demonstrated constitutive COX-2 expression to be a contributing factor promoting colorectal cancer (CRC). Various genetic, epigenetic, and inflammatory pathways have been identified to be involved in the etiology and development of CRC. Alteration in these pathways can influence COX-2 expression at multiple stages of colon carcinogenesis allowing for elevated prostanoid biosynthesis to occur in the tumor microenvironment. In normal cells, COX-2 expression levels are potently regulated at the post-transcriptional level through various RNA sequence elements present within the mRNA 3' untranslated region (3'UTR). A conserved AU-rich element (ARE) functions to target COX-2 mRNA for rapid decay and translational inhibition through association with various RNA-binding proteins to influence the fate of COX-2 mRNA. Specific microRNAs (miRNAs) bind regions within the COX-2 3'UTR and control COX-2 expression. In this chapter, we discuss novel insights in the mechanisms of altered post-transcriptional regulation of COX-2 in CRC and how this knowledge may be used to develop novel strategies for cancer prevention and treatment.

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X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 17%
Student > Ph. D. Student 8 15%
Other 7 13%
Student > Doctoral Student 3 6%
Student > Master 3 6%
Other 7 13%
Unknown 15 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 23%
Biochemistry, Genetics and Molecular Biology 9 17%
Medicine and Dentistry 9 17%
Immunology and Microbiology 3 6%
Nursing and Health Professions 2 4%
Other 2 4%
Unknown 15 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 March 2013.
All research outputs
#15,249,959
of 22,675,759 outputs
Outputs from Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer
#95
of 170 outputs
Outputs of similar age
#163,175
of 244,083 outputs
Outputs of similar age from Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer
#5
of 9 outputs
Altmetric has tracked 22,675,759 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 170 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,083 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.

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