| Chapter title |
Molecular Radio-Oncology
|
|---|---|
| Chapter number | 10 |
| Book title |
Molecular Radio-Oncology
|
| Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2016
|
| DOI | 10.1007/978-3-662-49651-0_10 |
| Pubmed ID | |
| Book ISBNs |
978-3-66-249649-7, 978-3-66-249651-0
|
| Authors |
Zschaeck, Sebastian, Steinbach, Jörg, Troost, Esther G C, Sebastian Zschaeck, Jörg Steinbach, Esther G.C. Troost, Troost, Esther G.C. |
| Abstract |
Tumour hypoxia is a well-known negative prognostic marker in almost all solid tumours. [18F]Fluoromisonidazole (FMISO)-positron emission tomography (PET) is a non-invasive method to detect tumour hypoxia. Compared to other methods of hypoxia assessment it possesses some considerable advantages: It is non-invasive, it delivers spatial information on the hypoxia distribution within the entire tumour volume, and it can be repeated during the course of radio(chemo)therapy. This chapter briefly describes different methods of hypoxia evaluation and focuses on hypoxia PET imaging, with the most commonly used tracer being FMISO. The preclinical rationale and clinical studies to use FMISO-PET for patient stratification in radiation therapy are discussed as well as possible agents or radiation-dose modifications to overcome hypoxia. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 13 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 5 | 38% |
| Student > Doctoral Student | 1 | 8% |
| Other | 1 | 8% |
| Researcher | 1 | 8% |
| Student > Postgraduate | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 4 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 46% |
| Psychology | 1 | 8% |
| Agricultural and Biological Sciences | 1 | 8% |
| Social Sciences | 1 | 8% |
| Engineering | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 23% |