Chapter title |
Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus.
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Book title |
Autoimmunity
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Published in |
Methods in molecular medicine, August 2004
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DOI | 10.1385/1-59259-805-6:087 |
Pubmed ID | |
Book ISBNs |
978-1-58829-231-5, 978-1-59259-805-2
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Authors |
Perl A, Nagy G, Gergely P, Puskas F, Qian Y, Banki K, Andras Perl, Gyorgy Nagy, Peter Gergely, Ferenc Puskas, Yueming Qian, Katalin Banki, Perl, Andras, Nagy, Gyorgy, Gergely, Peter, Puskas, Ferenc, Qian, Yueming, Banki, Katalin |
Abstract |
Systemic lupus erythematosus (SLE) is characterized by abnormal activation and cell death signaling within the immune system. Activation, proliferation, or death of cells of the immune system are dependent on controlled reactive oxygen intermediate (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta(Psi)m) reflects the energy stored in the electrochemical gradient across the inner mitochondrial membrane, which in turn is used by F0F1-ATPase to convert adenosine 5'-diphosphate to ATP during oxidative phosphorylation. Mitochondrial hyperpolarization and transient ATP depletion represent early and reversible steps in T-cell activation and apoptosis. By contrast, T lymphocytes of patients with SLE exhibit elevated Delta(Psi)m, that is, persistent mitochondrial hyperpolarization, cytoplasmic alkalinization, increased ROI production, as well as diminished levels of intracellular glutathione and ATP. Oxidative stress affects signaling through the T-cell receptor as well as the activity of redox-sensitive caspases. ATP depletion may be responsible for diminished activation-induced apoptosis and sensitize lupus T cells to necrosis. Mitochondrial dysfunction is identified as a key mechanism in the pathogenesis of SLE. |
X Demographics
Geographical breakdown
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United States | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 4 | 19% |
Student > Doctoral Student | 3 | 14% |
Unspecified | 2 | 10% |
Researcher | 2 | 10% |
Other | 1 | 5% |
Other | 4 | 19% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 29% |
Biochemistry, Genetics and Molecular Biology | 3 | 14% |
Unspecified | 2 | 10% |
Agricultural and Biological Sciences | 2 | 10% |
Immunology and Microbiology | 1 | 5% |
Other | 1 | 5% |
Unknown | 6 | 29% |