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Autoimmunity

Overview of attention for book
Attention for Chapter: Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus.
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Chapter title
Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus.
Book title
Autoimmunity
Published in
Methods in molecular medicine, August 2004
DOI 10.1385/1-59259-805-6:087
Pubmed ID
Book ISBNs
978-1-58829-231-5, 978-1-59259-805-2
Authors

Perl A, Nagy G, Gergely P, Puskas F, Qian Y, Banki K, Andras Perl, Gyorgy Nagy, Peter Gergely, Ferenc Puskas, Yueming Qian, Katalin Banki, Perl, Andras, Nagy, Gyorgy, Gergely, Peter, Puskas, Ferenc, Qian, Yueming, Banki, Katalin

Abstract

Systemic lupus erythematosus (SLE) is characterized by abnormal activation and cell death signaling within the immune system. Activation, proliferation, or death of cells of the immune system are dependent on controlled reactive oxygen intermediate (ROI) production and ATP synthesis in mitochondria. The mitochondrial transmembrane potential (Delta(Psi)m) reflects the energy stored in the electrochemical gradient across the inner mitochondrial membrane, which in turn is used by F0F1-ATPase to convert adenosine 5'-diphosphate to ATP during oxidative phosphorylation. Mitochondrial hyperpolarization and transient ATP depletion represent early and reversible steps in T-cell activation and apoptosis. By contrast, T lymphocytes of patients with SLE exhibit elevated Delta(Psi)m, that is, persistent mitochondrial hyperpolarization, cytoplasmic alkalinization, increased ROI production, as well as diminished levels of intracellular glutathione and ATP. Oxidative stress affects signaling through the T-cell receptor as well as the activity of redox-sensitive caspases. ATP depletion may be responsible for diminished activation-induced apoptosis and sensitize lupus T cells to necrosis. Mitochondrial dysfunction is identified as a key mechanism in the pathogenesis of SLE.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 19%
Student > Doctoral Student 3 14%
Unspecified 2 10%
Researcher 2 10%
Other 1 5%
Other 4 19%
Unknown 5 24%
Readers by discipline Count As %
Medicine and Dentistry 6 29%
Biochemistry, Genetics and Molecular Biology 3 14%
Unspecified 2 10%
Agricultural and Biological Sciences 2 10%
Immunology and Microbiology 1 5%
Other 1 5%
Unknown 6 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 February 2014.
All research outputs
#13,133,731
of 22,673,450 outputs
Outputs from Methods in molecular medicine
#35
of 53 outputs
Outputs of similar age
#47,236
of 53,783 outputs
Outputs of similar age from Methods in molecular medicine
#2
of 3 outputs
Altmetric has tracked 22,673,450 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 53 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,783 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.