Chapter title |
Shedding of cell membrane-bound proteoglycans.
|
---|---|
Chapter number | 19 |
Book title |
Proteoglycans
|
Published in |
Methods in molecular biology, January 2012
|
DOI | 10.1007/978-1-61779-498-8_19 |
Pubmed ID | |
Book ISBNs |
978-1-61779-497-1, 978-1-61779-498-8
|
Authors |
Eon Jeong Nam, Pyong Woo Park, Nam, Eon Jeong, Park, Pyong Woo |
Abstract |
Membrane-bound proteoglycans function primarily as coreceptors for many glycosaminoglycan (GAG)-binding ligands at the cell surface. The majority of membrane-bound proteoglycans can also function as soluble autocrine or paracrine effectors as their extracellular domains, replete with all GAG chains, are enzymatically cleaved and released from the cell surface by ectodomain shedding. In particular, the ectodomain shedding of syndecans, a major family of cell surface heparan sulfate proteoglycans, is an important posttranslational mechanism that modulates diverse pathophysiological processes. Syndecan shedding is a tightly controlled process that regulates the onset, progression, and resolution of various infectious and noninfectious inflammatory diseases. This review describes methods to induce and measure the shedding of cell membrane-bound proteoglycans, focusing on syndecan shedding as a prototypic example. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 3% |
Unknown | 36 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 27% |
Researcher | 5 | 14% |
Other | 4 | 11% |
Student > Master | 4 | 11% |
Student > Bachelor | 2 | 5% |
Other | 9 | 24% |
Unknown | 3 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 9 | 24% |
Medicine and Dentistry | 9 | 24% |
Agricultural and Biological Sciences | 7 | 19% |
Engineering | 2 | 5% |
Immunology and Microbiology | 2 | 5% |
Other | 4 | 11% |
Unknown | 4 | 11% |