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Metabolomics Tools for Natural Product Discovery

Overview of attention for book
Cover of 'Metabolomics Tools for Natural Product Discovery'

Table of Contents

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    Book Overview
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    Chapter 1 Bryophytes: liverworts, mosses, and hornworts: extraction and isolation procedures.
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    Chapter 2 Plant Tissue Extraction for Metabolomics
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    Chapter 3 Detection of polar metabolites through the use of gas chromatography-mass spectrometry.
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    Chapter 4 A Robust GC-MS Method for the Quantitation of Fatty Acids in Biological Systems
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    Chapter 5 A Workflow from Untargeted LC-MS Profiling to Targeted Natural Product Isolation
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    Chapter 6 Lipidomics: extraction protocols for biological matrices.
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    Chapter 7 Metabolite Analysis of Biological Fluids and Tissues by Proton Nuclear Magnetic Resonance Spectroscopy
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    Chapter 8 NMR Spectroscopy: Structure Elucidation of Cycloelatanene A: A Natural Product Case Study
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    Chapter 9 NMR-Based Metabolomics: A Probe to Utilize Biodiversity.
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    Chapter 10 Extraction Protocol for Nontargeted NMR and LC-MS Metabolomics-Based Analysis of Hard Coral and Their Algal Symbionts.
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    Chapter 11 Determination of absolute configuration using single crystal X-ray diffraction.
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    Chapter 12 Natural product chemistry in action: the synthesis of melatonin metabolites k1 and k 2.
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    Chapter 13 Discovery, biosynthesis, and rational engineering of novel enterocin and wailupemycin polyketide analogues.
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    Chapter 14 Bioassays for anticancer activities.
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    Chapter 15 Screening for antidiabetic activities.
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    Chapter 16 Screening for Antibacterial, Antifungal, and Anti quorum Sensing Activity.
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    Chapter 17 Metabolomics Tools for Natural Product Discovery
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    Chapter 18 Bridging the gap: basic metabolomics methods for natural product chemistry.
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    Chapter 19 Strategies in Biomarker Discovery. Peak Annotation by MS and Targeted LC-MS Micro-Fractionation for De Novo Structure Identification by Micro-NMR.
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    Chapter 20 Metabolomics Tools for Natural Product Discovery
Attention for Chapter 11: Determination of absolute configuration using single crystal X-ray diffraction.
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (77th percentile)
  • Good Attention Score compared to outputs of the same age and source (79th percentile)

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Citations

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Chapter title
Determination of absolute configuration using single crystal X-ray diffraction.
Chapter number 11
Book title
Metabolomics Tools for Natural Product Discovery
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-577-4_11
Pubmed ID
Book ISBNs
978-1-62703-576-7, 978-1-62703-577-4
Authors

Abigail L. Albright, Jonathan M. White

Editors

Ute Roessner, Daniel Anthony Dias

Abstract

Single crystal X-ray crystallography is the most powerful structural method for the determination of the 3D structures of molecules. While the results of a routine diffraction experiment readily provide unambiguous determination of the relative configuration of all stereogenic centers in the molecule, determination of absolute configuration is more challenging. This chapter provides some helpful tips towards increasing the chances of success in the determination of the absolute configuration of a chiral, enantiomerically pure natural product using X-ray crystallography.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 5%
Unknown 19 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 20%
Researcher 3 15%
Professor 2 10%
Student > Master 2 10%
Other 1 5%
Other 1 5%
Unknown 7 35%
Readers by discipline Count As %
Chemistry 11 55%
Physics and Astronomy 1 5%
Biochemistry, Genetics and Molecular Biology 1 5%
Unknown 7 35%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2016.
All research outputs
#5,899,293
of 22,877,793 outputs
Outputs from Methods in molecular biology
#1,718
of 13,132 outputs
Outputs of similar age
#62,025
of 281,318 outputs
Outputs of similar age from Methods in molecular biology
#69
of 340 outputs
Altmetric has tracked 22,877,793 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 13,132 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 281,318 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 340 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.