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Chapter title |
Quantitation of Plasma Membrane (G Protein-Coupled) Receptor Trafficking in Cultured Cells
|
---|---|
Chapter number | 26 |
Book title |
Endocannabinoid Signaling
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Published in |
Methods in molecular biology, January 2016
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DOI | 10.1007/978-1-4939-3539-0_26 |
Pubmed ID | |
Book ISBNs |
978-1-4939-3537-6, 978-1-4939-3539-0
|
Authors |
Jim Wager-Miller, Ken Mackie |
Editors |
Mauro Maccarrone |
Abstract |
Measuring the functional behavior of G protein-coupled receptors (GPCRs) has been a major focus of academic and pharmaceutical research for many decades. These efforts have led to the development of many assays to measure the downstream effects of ligand binding on receptor activity. In this chapter, we describe an internalization/recycling assay that can be used to track changes in receptor number at the plasma membrane. Used in concert with other assays, this antibody-based technique can provide important information on GPCR activation by receptor-specific ligands. |
Mendeley readers
The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 9 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 2 | 22% |
Student > Doctoral Student | 1 | 11% |
Student > Ph. D. Student | 1 | 11% |
Student > Master | 1 | 11% |
Researcher | 1 | 11% |
Other | 1 | 11% |
Unknown | 2 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 22% |
Agricultural and Biological Sciences | 2 | 22% |
Environmental Science | 1 | 11% |
Medicine and Dentistry | 1 | 11% |
Unknown | 3 | 33% |