Chapter title |
Hsp70 and Hsp90—a relay team for protein folding
|
---|---|
Book title |
Reviews of Physiology, Biochemistry and Pharmacology
|
Published in |
Reviews of Physiology, Biochemistry and Pharmacology, January 2004
|
DOI | 10.1007/s10254-003-0021-1 |
Pubmed ID | |
Book ISBNs |
978-3-54-022096-1, 978-3-54-044423-7
|
Authors |
Wegele H, Müller L, Buchner J, H. Wegele, L. Müller, J. Buchner, Wegele, H., Müller, L., Buchner, J. |
Abstract |
Molecular chaperones are a functionally defined set of proteins which assist the structure formation of proteins in vivo. Without certain protective mechanisms, such as binding nascent polypeptide chains by molecular chaperones, cellular protein concentrations would lead to misfolding and aggregation. In the mammalian system, the molecular chaperones Hsp70 and Hsp90 are involved in the folding and maturation of key regulatory proteins, like steroid hormone receptors, transcription factors, and kinases, some of which are involved in cancer progression. Hsp70 and Hsp90 form a multichaperone complex, in which both are connected by a third protein called Hop. The connection of and the interplay between the two chaperone machineries is of crucial importance for cell viability. This review provides a detailed view of the Hsp70 and Hsp90 machineries, their cofactors and their mode of regulation. It summarizes the current knowledge in the field, including the ATP-dependent regulation of the Hsp70/Hsp90 multichaperone cycle and elucidates the complex interplay and their synergistic interaction. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Portugal | 2 | <1% |
Spain | 2 | <1% |
Germany | 1 | <1% |
Australia | 1 | <1% |
South Africa | 1 | <1% |
United Kingdom | 1 | <1% |
Netherlands | 1 | <1% |
Russia | 1 | <1% |
Other | 3 | 1% |
Unknown | 245 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 65 | 25% |
Researcher | 34 | 13% |
Student > Bachelor | 33 | 13% |
Student > Master | 29 | 11% |
Student > Doctoral Student | 14 | 5% |
Other | 37 | 14% |
Unknown | 49 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 91 | 35% |
Biochemistry, Genetics and Molecular Biology | 66 | 25% |
Medicine and Dentistry | 12 | 5% |
Chemistry | 9 | 3% |
Neuroscience | 4 | 2% |
Other | 20 | 8% |
Unknown | 59 | 23% |