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HCV: The Journey from Discovery to a Cure

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Cover of 'HCV: The Journey from Discovery to a Cure'

Table of Contents

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    Book Overview
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    Chapter 33 From B to Non-B to C: The Hepatitis C Virus in Historical Perspective
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    Chapter 34 The Hepatitis C Virus Replicon System and Its Role in Drug Development
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    Chapter 35 Evolution of HCV NS5B Non-nucleoside Inhibitors
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    Chapter 36 Evolution of HCV NS5B Nucleoside and Nucleotide Inhibitors
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    Chapter 37 The Discovery of Sofosbuvir: A Liver-Targeted Nucleotide Prodrug for the Treatment and Cure of HCV
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    Chapter 38 Discovery of Beclabuvir: A Potent Allosteric Inhibitor of the Hepatitis C Virus Polymerase
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    Chapter 39 Evolution of HCV NS3/4a Protease Inhibitors
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    Chapter 40 Discovery of Boceprevir, a Ketoamide-Derived HCV NS3 Protease Inhibitor, for Treatment of Genotype 1 Infections
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    Chapter 41 The Invention of Grazoprevir: An HCV NS3/4a Protease Inhibitor
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    Chapter 42 The Discovery and Development of HCV NS3 Protease Inhibitor Paritaprevir
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    Chapter 51 HCV Molecular Virology and Animal Models
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    Chapter 53 The Discovery of the Hepatitis C Virus
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    Chapter 55 Discovery and Development of the Next-Generation HCV NS3 Protease Inhibitor Glecaprevir
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    Chapter 57 Development and Marketing of INCIVEK (Telaprevir; VX-950): A First-Generation HCV Protease Inhibitor, in Combination with PEGylated Interferon and Ribavirin
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    Chapter 58 The Discovery and Early Clinical Evaluation of the HCV NS3/4A Protease Inhibitor Asunaprevir (BMS-650032)
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    Chapter 59 The Role of Interferon for the Treatment of Chronic Hepatitis C Virus Infection
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    Chapter 61 Discovery of Voxilaprevir (GS-9857): The Pan-Genotypic Hepatitis C Virus NS3/4A Protease Inhibitor Utilized as a Component of Vosevi ®
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