| Chapter title |
Transposable Elements.
|
|---|---|
| Chapter number | 112 |
| Book title |
Behavioral Neurogenomics
|
| Published in |
Current topics in behavioral neurosciences, October 2019
|
| DOI | 10.1007/7854_2019_112 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-031264-0, 978-3-03-031265-7
|
| Authors |
Guffanti, G, Bartlett, A, DeCrescenzo, P, Macciardi, F, Hunter, R, G. Guffanti, A. Bartlett, P. DeCrescenzo, F. Macciardi, R. Hunter, Guffanti, G., Bartlett, A., DeCrescenzo, P., Macciardi, F., Hunter, R. |
| Abstract |
Transposable elements (TEs) are low-complexity elements (e.g., LINEs, SINEs, SVAs, and HERVs) that make up to two-thirds of the human genome. There is mounting evidence that TEs play an essential role in molecular functions that influence genomic plasticity and gene expression regulation. With the advent of next-generation sequencing approaches, our understanding of the relationship between TEs and psychiatric disorders will greatly improve. In this chapter, the Authors comprehensively summarize the state-of the-art of TE research in animal models and humans supporting a framework in which TEs play a functional role in mechanisms affecting a variety of behaviors, including neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. Finally, the Authors discuss recent therapeutic applications raised from the increasing experimental evidence on TE functional mechanisms. |
X Demographics
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|---|---|---|
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| United Kingdom | 1 | 14% |
| Unknown | 4 | 57% |
Demographic breakdown
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| Members of the public | 3 | 43% |
Mendeley readers
Geographical breakdown
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|---|---|---|
| United States | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 7 | 19% |
| Student > Ph. D. Student | 7 | 19% |
| Researcher | 5 | 14% |
| Student > Bachelor | 4 | 11% |
| Student > Doctoral Student | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 11 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 10 | 28% |
| Agricultural and Biological Sciences | 9 | 25% |
| Neuroscience | 3 | 8% |
| Psychology | 2 | 6% |
| Immunology and Microbiology | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 9 | 25% |