Cell Biology and Translational Medicine, Volume 13
Springer International Publishing
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Attention Score in Context
| Chapter title |
The Design and Application of an Appropriate Parkinson's Disease Animal Model in Regenerative Medicine.
|
|---|---|
| Book title |
Cell Biology and Translational Medicine, Volume 13
|
| Published in |
Advances in experimental medicine and biology, September 2019
|
| DOI | 10.1007/5584_2019_422 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-079057-8, 978-3-03-079058-5
|
| Authors |
Larijani, Bagher, Goodarzi, Parisa, Payab, Moloud, Tayanloo-Beik, Akram, Sarvari, Masoumeh, Gholami, Mahdi, Gilany, Kambiz, Nasli-Esfahani, Ensieh, Yarahmadi, Mehrnoosh, Ghaderi, Firoozeh, Arjmand, Babak |
| Abstract |
Aging as an inevitable and complex physiological process occurs through a progressive decrease in the potential of tissue regeneration. Given the increasing global outbreak of aging and age-related disorders, it is important to control this phenomenon. Parkinson's disease (one of the age-related neurodegenerative and progressive disorders) resulted from predominant dopaminergic neurons deficiency. Usual Parkinson's disease treatments just can lead to symptomatically relieving. Recently, cell therapy and regenerative medicine a great promise in the treatment of several types of disorders including Parkinson's disease. Herein, before starting clinical trials, preclinical studies should be performed to answer some fundamental questions about the safety and efficacy of various treatments. Additionally, developing a well-designed and approved study is required to provide an appropriate animal model with strongly reliable validation methods. Hereupon, this review will discuss about the design and application of an appropriate Parkinson's disease animal model in regenerative medicine. In order to conduct the present review, numbers of Parkinson's disease preclinical studies, as well as literatures related to the animal modeling, were considered. Appropriate animal models which approved by related authorize committees should have a high similarity to humans from anatomical, physiological, behavioral, and genetic characteristics view of point. It is concluded that animal studies before starting clinical trials have an important role in answering the crucial questions about the various treatments safety and efficacy. Therein, it is recommended that all of animal modeling stages be assessed by animal ethics and welfare guidelines and also evaluated by different validation tests. However, it is better to find some alternatives to replacement, refinement, and, reduction of animals. Nowadays, some novel technologies such as using imaging methods have been introduced. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 31 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 13% |
| Student > Master | 4 | 13% |
| Student > Doctoral Student | 3 | 10% |
| Student > Bachelor | 3 | 10% |
| Other | 2 | 6% |
| Other | 3 | 10% |
| Unknown | 12 | 39% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 10% |
| Veterinary Science and Veterinary Medicine | 2 | 6% |
| Computer Science | 2 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
| Neuroscience | 2 | 6% |
| Other | 9 | 29% |
| Unknown | 11 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 September 2019.
All research outputs
#3,181,618
of 23,155,957 outputs
Outputs from Advances in experimental medicine and biology
#528
of 4,984 outputs
Outputs of similar age
#66,472
of 340,674 outputs
Outputs of similar age from Advances in experimental medicine and biology
#15
of 54 outputs
Altmetric has tracked 23,155,957 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,984 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 340,674 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.