Report for: Astrocytes

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Chapter title	Reprogramming of postnatal astroglia of the mouse neocortex into functional, synapse-forming neurons.
Chapter number	32
Book title	Astrocytes
Published in	Methods in molecular biology, December 2011
DOI	10.1007/978-1-61779-452-0_32
Pubmed ID	22144327
Book ISBNs	978-1-61779-451-3, 978-1-61779-452-0
Authors	Heinrich C, Götz M, Berninger B, Christophe Heinrich, Magdalena Götz, Benedikt Berninger
Abstract	Direct conversion of glia into neurons by cellular reprogramming represents a novel approach toward a cell-based therapy of neurodegenerative processes. Here we describe a protocol that allows for the direct and efficient in vitro reprogramming of mouse astroglia from the early postnatal neocortex by forced expression of single neurogenic fate determinants. By selective retrovirus-mediated expression of neurogenin-2 (Neurog2) on the one hand, or the mouse homologue of Distal-less Dlx2 or the mammalian homologue of achaete-schute-1 (Mash1) on the other, it is possible to drive postnatal astroglia in culture toward the genesis of fully functional, synapse-forming, glutamatergic, i.e., excitatory, and GABAergic, i.e., inhibitory, neurons, respectively.

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Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Chile	1	2%
Portugal	1	2%
Unknown	40	95%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	11	26%
Researcher	6	14%
Student > Bachelor	4	10%
Student > Master	4	10%
Professor	3	7%
Other	6	14%
Unknown	8	19%

Readers by discipline	Count	As %
Neuroscience	13	31%
Agricultural and Biological Sciences	10	24%
Biochemistry, Genetics and Molecular Biology	6	14%
Medicine and Dentistry	3	7%
Psychology	1	2%
Other	2	5%
Unknown	7	17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 February 2012.

All research outputs

#20,155,513

of 22,663,150 outputs

Outputs from Methods in molecular biology

#9,800

of 13,021 outputs

Outputs of similar age

#218,971

of 240,850 outputs

Outputs of similar age from Methods in molecular biology

#410

of 463 outputs

Altmetric has tracked 22,663,150 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.

So far Altmetric has tracked 13,021 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

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We're also able to compare this research output to 463 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

Astrocytes

Table of Contents

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Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context