| Chapter title |
Oncogenic mutations of PIK3CA in human cancers.
|
|---|---|
| Chapter number | 68 |
| Book title |
Phosphoinositide 3-kinase in Health and Disease
|
| Published in |
Current topics in microbiology and immunology, January 2010
|
| DOI | 10.1007/82_2010_68 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-214815-6, 978-3-64-214816-3
|
| Authors |
Samuels, Yardena, Waldman, Todd, Yardena Samuels, Todd Waldman |
| Abstract |
The involvement of the PIK3CA gene product p110α, the catalytic subunit of phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 years, and support for this proposal had been provided by both genetic and functional studies, including most recently the discovery of common activating missense mutations of PIK3CA in a wide variety of common human tumor types. This chapter will focus on the discovery of these mutations and describes their relevance to a wide range of common human tumor types.Of note, the identification and functional analysis of the PIK3CA gene are reviewed in other chapters in this book. However, a brief mention will be made here of its general properties as background to our focus on the discovery of its cancer-specific mutations. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 97 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 19 | 20% |
| Student > Ph. D. Student | 17 | 18% |
| Researcher | 10 | 10% |
| Student > Postgraduate | 5 | 5% |
| Student > Master | 5 | 5% |
| Other | 8 | 8% |
| Unknown | 33 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 28 | 29% |
| Medicine and Dentistry | 17 | 18% |
| Agricultural and Biological Sciences | 10 | 10% |
| Chemistry | 4 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 2% |
| Other | 2 | 2% |
| Unknown | 34 | 35% |