Chapter title |
Modeling depression in animal models.
|
---|---|
Chapter number | 7 |
Book title |
Psychiatric Disorders
|
Published in |
Methods in molecular biology, January 2012
|
DOI | 10.1007/978-1-61779-458-2_7 |
Pubmed ID | |
Book ISBNs |
978-1-61779-457-5, 978-1-61779-458-2
|
Authors |
David H. Overstreet, Overstreet, David H. |
Abstract |
Animal models and preclinical tests have played large roles in the development of antidepressant drugs and are likely to continue to play important roles. In the present communication, the main animal models of depression have been described and reviewed. These models include the Flinders sensitive line (FSL) rat, the Wistar Kyoto (WKY) rat, the fawn-hooded (FH) rat, and the learned helpless (LH) rat. In addition, the materials used to assess the behavior of these rats, including swim tanks, drinking tubes, and an open field apparatus, have been discussed. Finally, the methods used in collecting the relevant behaviors in the animal models are described. These include the procedures used in the forced swim test and chronic mild stress protocols, including the sucrose preference test. It is concluded that the behavioral tests used to infer depressed-like behavior in rats will continue to provide useful data if the appropriate animals and proper methods are used. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Brazil | 2 | 1% |
Canada | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 169 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 43 | 25% |
Researcher | 28 | 16% |
Student > Master | 20 | 12% |
Student > Bachelor | 17 | 10% |
Student > Doctoral Student | 13 | 8% |
Other | 28 | 16% |
Unknown | 24 | 14% |
Readers by discipline | Count | As % |
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Neuroscience | 41 | 24% |
Agricultural and Biological Sciences | 31 | 18% |
Medicine and Dentistry | 21 | 12% |
Biochemistry, Genetics and Molecular Biology | 13 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 10 | 6% |
Other | 18 | 10% |
Unknown | 39 | 23% |