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Proteoglycans

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Cover of 'Proteoglycans'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Proteoglycans: Gene Cloning
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    Chapter 2 Proteoglycan: Site Mapping and Site-Directed Mutagenesis
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    Chapter 3 Mapping of the Wnt/β-Catenin/TCF Response Elements in the Human Versican Promoter
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    Chapter 4 Gene Silencing in Mouse Embryonic Stem Cells
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    Chapter 5 A Novel Strategy for a Splice-Variant Selective Gene Ablation: The Example of the Versican V0/V2 Knockout
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    Chapter 6 Detection of Neurocan in Cerebrospinal Fluid
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    Chapter 7 Glycosaminoglycan Chain Analysis and Characterization (Glycosylation/Epimerization)
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    Chapter 8 Characterization of Glycosaminoglycans by Tandem Vibrational Microspectroscopy and Multivariate Data Analysis
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    Chapter 9 Glycosaminoglycans: Oligosaccharide Analysis by Liquid Chromatography, Capillary Electrophoresis, and Specific Labeling
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    Chapter 10 Brain Chondroitin/Dermatan Sulfate, from Cerebral Tissue to Fine Structure: Extraction, Preparation, and Fully Automated Chip-Electrospray Mass Spectrometric Analysis
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    Chapter 11 Use of Neutrons Reveals the Dynamics of Cell Surface Glycosaminoglycans
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    Chapter 12 Proteoglycans
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    Chapter 13 In Vivo Scintigraphic Imaging of Proteoglycans
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    Chapter 14 Serglycin: The Master of the Mast Cell
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    Chapter 15 Analysis of Aggrecan Catabolism by Immunoblotting and Immunohistochemistry
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    Chapter 16 Heparan sulfate proteoglycans as multifunctional cell regulators: cell surface receptors.
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    Chapter 17 Models for Studies of Proteoglycans in Kidney Pathophysiology
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    Chapter 18 Lumican Promotes Corneal Epithelial Wound Healing
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    Chapter 19 Shedding of cell membrane-bound proteoglycans.
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    Chapter 20 Proteoglycans
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    Chapter 21 Proteoglycans
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    Chapter 22 Proteoglycans and Cartilage Repair
Attention for Chapter 16: Heparan sulfate proteoglycans as multifunctional cell regulators: cell surface receptors.
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Chapter title
Heparan sulfate proteoglycans as multifunctional cell regulators: cell surface receptors.
Chapter number 16
Book title
Proteoglycans
Published in
Methods in molecular biology, January 2012
DOI 10.1007/978-1-61779-498-8_16
Pubmed ID
Book ISBNs
978-1-61779-497-1, 978-1-61779-498-8
Authors

Li JP, Spillmann D, Jin-ping Li, Dorothe Spillmann, Li, Jin-ping, Spillmann, Dorothe

Abstract

Proteoglycans are macromolecules expressed on the cell surfaces and in the extracellular matrix of most animal tissues (Annu Rev Biochem 68:729-777, 1999; Int Rev Cell Mol Biol 276:105-159, 2009). Heparan sulfate proteoglycans (HSPGs) are essential for animal development and homeostasis, and are involved in various pathological processes. The functions of HSPGs are largely exerted through interaction of the heparan sulfate (HS) side chains with different types of ligands, including diverse molecules such as cytokines, enzymes, and pathogens. One of the important roles of cell surface HSPGs is to mediate cytokine-induced cell signaling through interaction with growth factors (GFs) and their cognate receptors. A selective dependence of GFs for different structural features of HS has been demonstrated by applying cell models that are mutated variously in HS structure due to deficiency in enzymes involved in the biosynthesis of HS chains.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 17%
Unknown 5 83%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 1 17%
Student > Ph. D. Student 1 17%
Researcher 1 17%
Professor > Associate Professor 1 17%
Student > Postgraduate 1 17%
Other 0 0%
Unknown 1 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 33%
Agricultural and Biological Sciences 1 17%
Immunology and Microbiology 1 17%
Chemistry 1 17%
Unknown 1 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2012.
All research outputs
#18,303,566
of 22,661,413 outputs
Outputs from Methods in molecular biology
#7,811
of 13,020 outputs
Outputs of similar age
#196,290
of 246,013 outputs
Outputs of similar age from Methods in molecular biology
#320
of 471 outputs
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So far Altmetric has tracked 13,020 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 471 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.