Chapter title |
Patho-epigenetics of Infectious Diseases Caused by Intracellular Bacteria.
|
---|---|
Chapter number | 6 |
Book title |
Patho-Epigenetics of Infectious Disease
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-24738-0_6 |
Pubmed ID | |
Book ISBNs |
978-3-31-924736-6, 978-3-31-924738-0
|
Authors |
Niller, Hans Helmut, Minarovits, Janos, Hans Helmut Niller, Janos Minarovits |
Abstract |
In multicellular eukaryotes including plants, animals and humans, epigenetic reprogramming may play a role in the pathogenesis of a wide variety of diseases. Recent studies revealed that in addition to viruses, pathogenic bacteria are also capable to dysregulate the epigenetic machinery of their target cells. In this chapter we focus on epigenetic alterations induced by bacteria infecting humans. Most of them are obligate or facultative intracellular bacteria that produce either bacterial toxins and surface proteins targeting the host cell membrane, or synthesise effector proteins entering the host cell nucleus. These bacterial products typically elicit histone modifications, i.e. alter the "histone code". Bacterial pathogens are capable to induce alterations of host cell DNA methylation patterns, too. Such changes in the host cell epigenotype and gene expression pattern may hinder the antibacterial immune response and create favourable conditions for bacterial colonization, growth, or spread. Epigenetic dysregulation mediated by bacterial products may also facilitate the production of inflammatory cytokines and other inflammatory mediators affecting the epigenotype of their target cells. Such indirect epigenetic changes as well as direct interference with the epigenetic machinery of the host cells may contribute to the initiation and progression of malignant tumors associated with distinct bacterial infections. |
X Demographics
Geographical breakdown
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France | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 2% |
Spain | 1 | 2% |
Netherlands | 1 | 2% |
United States | 1 | 2% |
Unknown | 43 | 91% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 9 | 19% |
Researcher | 7 | 15% |
Student > Doctoral Student | 5 | 11% |
Student > Bachelor | 4 | 9% |
Professor > Associate Professor | 3 | 6% |
Other | 7 | 15% |
Unknown | 12 | 26% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 9 | 19% |
Agricultural and Biological Sciences | 9 | 19% |
Nursing and Health Professions | 5 | 11% |
Immunology and Microbiology | 3 | 6% |
Environmental Science | 2 | 4% |
Other | 4 | 9% |
Unknown | 15 | 32% |