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Aging and Aging-Related Diseases

Overview of attention for book
Cover of 'Aging and Aging-Related Diseases'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Systems Biology in Aging Research
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    Chapter 2 Circular RNA in Aging and Age-Related Diseases
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    Chapter 3 Noncoding RNAs in Cardiovascular Aging
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    Chapter 4 Epigenetic Regulation of Vascular Aging and Age-Related Vascular Diseases
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    Chapter 5 ApoE and Neurodegenerative Diseases in Aging
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    Chapter 6 Brain Aging: Hsp90 and Neurodegenerative Diseases
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    Chapter 7 Aging of Human Adult Stem Cells
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    Chapter 8 Mechanisms of Hematopoietic Stem Cell Ageing and Targets for Hematopoietic Tumour Prevention
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    Chapter 9 Microbiota and Aging
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    Chapter 10 Intestinal Homeostasis and Longevity: Drosophila Gut Feeling
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    Chapter 11 Aging Kidney and Aging-Related Disease
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    Chapter 12 Aging of the Bone
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    Chapter 13 Ovarian Aging and Osteoporosis
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    Chapter 14 Biomarkers of Aging
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    Chapter 15 Pharmaceutical Intervention of Aging
  17. Altmetric Badge
    Chapter 16 Application of Stem Cell Technology in Antiaging and Aging-Related Diseases
  18. Altmetric Badge
    Chapter 17 Which is the Most Reasonable Anti-aging Strategy: Meta-analysis
Attention for Chapter 5: ApoE and Neurodegenerative Diseases in Aging
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Chapter title
ApoE and Neurodegenerative Diseases in Aging
Chapter number 5
Book title
Aging and Aging-Related Diseases
Published in
Advances in experimental medicine and biology, January 2018
DOI 10.1007/978-981-13-1117-8_5
Pubmed ID
30232753
Book ISBNs
978-9-81-131116-1, 978-9-81-131117-8
Authors

Yuemiao Yin, Zhao Wang, Yin, Yuemiao, Wang, Zhao

Abstract

Age and apolipoprotein E (ApoE) are the mightiest risk factors for dementia and cardiovascular diseases, but the underlying mechanisms remain unclear. In human, ApoE has three isoforms, ApoE2, ApoE3, and ApoE4, which are expressed by the polymorphic alleles: ɛ2, ɛ3, and ɛ4. Among the three polymorphic alleles, apoE ε4 is the most risk gene. ApoE is the main ligand for the low-density lipoprotein (LDL) receptor and the LDL receptor-related protein (LRP), functioning as the component of plasma lipoproteins in the transportation of lipids. Physiologically, ApoE is a multifunctional protein with central roles in lipid metabolism; it transports lipids, including cholesterol, through the cerebrospinal fluid (CSF) and plasma. ApoE expression regulation and apoE gene polymorphism have an important connection with neurological or neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), ischemic stroke, and other diseases.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 121 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 121 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 21 17%
Student > Ph. D. Student 18 15%
Student > Master 13 11%
Researcher 10 8%
Student > Doctoral Student 6 5%
Other 8 7%
Unknown 45 37%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 26 21%
Medicine and Dentistry 12 10%
Agricultural and Biological Sciences 9 7%
Neuroscience 8 7%
Nursing and Health Professions 3 2%
Other 14 12%
Unknown 49 40%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2018.
All research outputs
#18,649,666
of 23,103,903 outputs
Outputs from Advances in experimental medicine and biology
#3,336
of 4,976 outputs
Outputs of similar age
#330,932
of 442,720 outputs
Outputs of similar age from Advances in experimental medicine and biology
#154
of 237 outputs
Altmetric has tracked 23,103,903 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,976 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.

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