| Chapter title |
Partial Protection Induced by 2011-2012 Influenza Vaccine Against Serologically Evidenced A(H3N2) Influenza Virus Infections in Elderly Institutionalized People.
|
|---|---|
| Chapter number | 5003 |
| Book title |
Advances in Microbiology, Infectious Diseases and Public Health
|
| Published in |
Advances in experimental medicine and biology, November 2015
|
| DOI | 10.1007/5584_2015_5003 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-926319-9, 978-3-31-926320-5
|
| Authors |
Camilloni, Barbara, Basileo, Michela, Menculini, Giuseppe, Tozzi, Paolo, Iorio, Anna Maria, Barbara Camilloni, Michela Basileo, Giuseppe Menculini, Paolo Tozzi, Anna Maria Iorio |
| Editors |
Gianfranco Donelli |
| Abstract |
Ninety-two institutionalized elderly subjects were vaccinated with trivalent influenza inactivated vaccine available for the 2011-2012 season, characterized by a prevalent circulation of A(H3N2) influenza viruses (A/Victoria/208-clade) presenting antigenic and genetic patterns different from the A(H3N2) vaccine component (A/Perth/16/2009-clade). Haemagglutination inhibiting (HI) antibody titers were determined in sera collected before, 1 and 6 months after vaccination and patients were considered positive for serological evidence of recent infection if they had a seroconversion on comparing HI titers found in sera collected 1 and 6 months after vaccination. No seroconversions were found against A(H1N1) and B vaccine components. Instead 17 volunteers seroconverted against all or at least some of the different A(H3N2) antigens examined, i.e. the 2011-2012 (A/Perth/16/2009) and the 2012-2013 (A/Victoria/361/2011) vaccine strains and four drifted viruses belonging to the A/Victoria/208-clade circulating in the area were the elderly people were living. The results obtained suggest that influenza infections in the vaccinated volunteers might be due both to a poor match between vaccine and circulating A(H3N2) viruses, since 1 month after vaccination 15 of the 17 volunteers had post-vaccination HI titers considered protective (≥40) against the A(H3N2) vaccine antigen, but not always against the epidemic strains, and to a waning of vaccine induced immune response, since 6 months after vaccination HI titers of non-infected volunteers were found to be decreased as compared with those found 1 month after vaccination. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 3 | 27% |
| Other | 2 | 18% |
| Student > Master | 2 | 18% |
| Student > Doctoral Student | 1 | 9% |
| Researcher | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 27% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Veterinary Science and Veterinary Medicine | 1 | 9% |
| Agricultural and Biological Sciences | 1 | 9% |
| Other | 3 | 27% |
| Unknown | 1 | 9% |