Chapter title |
In Vitro Activity of Tigecycline Against Acinetobacter baumannii: Global Epidemiology and Resistance Mechanisms
|
---|---|
Chapter number | 5001 |
Book title |
Advances in Microbiology, Infectious Diseases and Public Health
|
Published in |
Advances in experimental medicine and biology, November 2015
|
DOI | 10.1007/5584_2015_5001 |
Pubmed ID | |
Book ISBNs |
978-3-31-926319-9, 978-3-31-926320-5
|
Authors |
Pournaras, Spyros, Koumaki, Vasiliki, Gennimata, Vasiliki, Kouskouni, Evangelia, Tsakris, Athanassios, Spyros Pournaras, Vasiliki Koumaki, Vasiliki Gennimata, Evangelia Kouskouni, Athanassios Tsakris |
Abstract |
Acinetobacter baumannii is a pathogen of increasing concern, commonly causing outbreaks in the hospital environment. Of particular concern, A. baumannii strains exhibiting resistance to carbapenems, which were previously considered the treatment of choice for infected patients, have dramatically increased worldwide, leaving a few antibacterial choices. Tigecycline, a broad-spectrum modified minocycline derivative, isconsidered as a last resort drug against multidrug-resistant A. baumannii. Though, resistance to tigecycline has emerged and is growing notably following increasing tigecycline usage. Comparative evaluation of the tigecycline resistance rates reported worldwide is challenging due to the absence of official interpretative criteria for in vitro susceptibility testing and the discrepancies among the different susceptibility methodologies used, with broth microdilution being considered the reference method. Tigecycline resistance is mainly associated with resistance-nodulation-cell division (RND)-type transporters, mainly the AdeABC, AdeFGH and AdeIJK efflux pumps, but other resistance mechanisms have also been implicated. Tigecycline is still an attractive choice for A. baumannii , but further investigations are warranted so that treatment of MDR Α. baumannii could be guided by validated in vitro data. |
X Demographics
Geographical breakdown
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Pakistan | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 38 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 13% |
Student > Postgraduate | 5 | 13% |
Researcher | 4 | 11% |
Student > Master | 3 | 8% |
Student > Ph. D. Student | 3 | 8% |
Other | 6 | 16% |
Unknown | 12 | 32% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 12 | 32% |
Immunology and Microbiology | 3 | 8% |
Agricultural and Biological Sciences | 3 | 8% |
Veterinary Science and Veterinary Medicine | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Other | 2 | 5% |
Unknown | 16 | 42% |