Chapter title |
Infectious Agents Associated with Head and Neck Carcinomas.
|
---|---|
Chapter number | 5005 |
Book title |
Advances in Microbiology, Infectious Diseases and Public Health
|
Published in |
Advances in experimental medicine and biology, November 2015
|
DOI | 10.1007/5584_2015_5005 |
Pubmed ID | |
Book ISBNs |
978-3-31-926319-9, 978-3-31-926320-5
|
Authors |
Hettmann, Andrea, Demcsák, Anett, Decsi, Gábor, Bach, Ádám, Pálinkó, Dóra, Rovó, László, Nagy, Katalin, Takács, Mária, Minarovits, Janos, Andrea Hettmann, Anett Demcsák, Gábor Decsi, Ádám Bach, Dóra Pálinkó, László Rovó, Katalin Nagy, Mária Takács, Janos Minarovits |
Editors |
Gianfranco Donelli |
Abstract |
In addition to traditional risk factors such as smoking habits and alcohol consumption, certain microbes also play an important role in the generation of head and neck carcinomas. Infection with high-risk human papillomavirus types is strongly associated with the development of oropharyngeal carcinoma, and Epstein-Barr virus appears to be indispensable for the development of non-keratinizing squamous cell carcinoma of the nasopharynx. Other viruses including torque teno virus and hepatitis C virus may act as co-carcinogens, increasing the risk of malignant transformation. A shift in the composition of the oral microbiome was associated with the development of oral squamous cell carcinoma, although the causal or casual role of oral bacteria remains to be clarified. Conversion of ethanol to acetaldehyde, a mutagenic compound, by members of the oral microflora as well as by fungi including Candida albicans and others is a potential mechanism that may increase oral cancer risk. In addition, distinct Candida spp. also produce NBMA (N-nitrosobenzylmethylamine), a potent carcinogen. Inflammatory processes elicited by microbes may also facilitate tumorigenesis in the head and neck region. |
X Demographics
Geographical breakdown
Country | Count | As % |
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France | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 68 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 12 | 18% |
Other | 7 | 10% |
Researcher | 6 | 9% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 4 | 6% |
Other | 16 | 24% |
Unknown | 18 | 26% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 25 | 37% |
Biochemistry, Genetics and Molecular Biology | 7 | 10% |
Agricultural and Biological Sciences | 4 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Unspecified | 2 | 3% |
Other | 7 | 10% |
Unknown | 20 | 29% |