| Chapter title |
An Introduction to Epigenetics in Cardiovascular Development, Disease, and Sexualization. - PubMed - NCBI
|
|---|---|
| Chapter number | 2 |
| Book title |
Sex-Specific Analysis of Cardiovascular Function
|
| Published in |
Advances in experimental medicine and biology, July 2018
|
| DOI | 10.1007/978-3-319-77932-4_2 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-977931-7, 978-3-31-977932-4
|
| Authors |
Cunningham, Christine M, Eghbali, Mansoureh, Christine M. Cunningham, Mansoureh Eghbali, Cunningham, Christine M. |
| Abstract |
Epigenetic regulation of gene expression is integral to cell differentiation, development, and disease. Modes of epigenetic regulation-including DNA methylation, histone modifications, and ncRNA-based regulation-alter chromatin structure, promotor accessibility, and contribute to posttranscriptional modifications. In the cardiovascular system, epigenetic regulation is necessary for proper cardiovascular development and homeostasis, while epigenetic dysfunction is associated with improper cardiac development and disease.Early sexualization of tissues, including X-inactivation in females and maternal and paternal imprinting, is also orchestrated through epigenetic mechanisms. Furthermore, sex chromosomes encode various sex-specific genes involved in epigenetic regulation, while sex hormones can act as regulatory cofactors that may predispose or protect males and females against developing diseases with a marked sex bias.The following book chapter summarizes the field of epigenetics in the context of cardiovascular development and disease while also highlighting the role of epigenetic regulation as a powerful source of sex differences within the cardiovascular system. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 16 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 19% |
| Student > Doctoral Student | 2 | 13% |
| Student > Ph. D. Student | 2 | 13% |
| Other | 1 | 6% |
| Professor | 1 | 6% |
| Other | 3 | 19% |
| Unknown | 4 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 31% |
| Medicine and Dentistry | 3 | 19% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Physics and Astronomy | 1 | 6% |
| Immunology and Microbiology | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 5 | 31% |