Chapter title |
Potential Use of Stem Cells in Mood Disorders. - PubMed - NCBI
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Chapter number | 250 |
Book title |
Cell Biology and Translational Medicine, Volume 2
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Published in |
Advances in experimental medicine and biology, July 2018
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DOI | 10.1007/5584_2018_250 |
Pubmed ID | |
Book ISBNs |
978-3-03-004169-4, 978-3-03-004170-0
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Authors |
Colpo, Gabriela D, Stertz, Laura, Dinz, Breno S, Teixeira, Antonio L, Gabriela D. Colpo, Laura Stertz, Breno S. Diniz, Antonio L. Teixeira, Colpo, Gabriela D., Diniz, Breno S., Teixeira, Antonio L. |
Abstract |
Mood disorders are heterogeneous conditions characterized by complex genetics, unclear pathophysiology, and variable symptomatology. Currently, there is no biomarker for the diagnosis or prognosis of mood disorders, and the treatments are of limited efficacy in a significant proportion of patients. Furthermore, the disease models are not able to recapitulate their complexity. In this scenario, stem cells may have different applications in mood disorders. Circulating stem cells may be regarded as potential biomarkers. Mesenchymal stem cells are a promising therapeutic strategy for mood disorders as they promote neurogenesis and increase the expression of neurotrophic factors that enhance the survival and differentiation of neurons. In addition, induced pluripotent stem cells, cells reprogrammed from somatic cells of healthy subjects or patients, offer a great opportunity to recapitulate both normal and pathological development of human brain tissues, thereby opening a new avenue for disease modeling and drug development in a more disease-relevant system. |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 22 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 3 | 14% |
Student > Ph. D. Student | 2 | 9% |
Researcher | 2 | 9% |
Student > Bachelor | 2 | 9% |
Unknown | 13 | 59% |
Readers by discipline | Count | As % |
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Neuroscience | 5 | 23% |
Biochemistry, Genetics and Molecular Biology | 2 | 9% |
Psychology | 1 | 5% |
Unknown | 14 | 64% |