Chapter title |
Cellular Determinants of HIV Persistence on Antiretroviral Therapy
|
---|---|
Chapter number | 9 |
Book title |
HIV Vaccines and Cure
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-981-13-0484-2_9 |
Pubmed ID | |
Book ISBNs |
978-9-81-130483-5, 978-9-81-130484-2
|
Authors |
Anastassia Mikhailova, Jose Carlos Valle-Casuso, Asier Sáez-Cirión, Mikhailova, Anastassia, Valle-Casuso, Jose Carlos, Sáez-Cirión, Asier |
Abstract |
The era of antiretroviral therapy has made HIV-1 infection a manageable chronic disease for those with access to treatment. Despite treatment, virus persists in tissue reservoirs seeded with long-lived infected cells that are resistant to cell death and immune recognition. Which cells contribute to this reservoir and which factors determine their persistence are central questions that need to be answered to achieve viral eradication. In this chapter, we describe how cell susceptibility to infection, resistance to cell death, and immune-mediated killing as well as natural cell life span and turnover potential are central components that allow persistence of different lymphoid and myeloid cell subsets that were recently identified as key players in harboring latent and actively replicating virus. The relative contribution of these subsets to persistence of viral reservoir is described, and the open questions are highlighted. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 50% |
United Kingdom | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 50% |
Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 19 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 26% |
Student > Ph. D. Student | 4 | 21% |
Professor | 2 | 11% |
Student > Master | 1 | 5% |
Student > Doctoral Student | 1 | 5% |
Other | 0 | 0% |
Unknown | 6 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 5 | 26% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Medicine and Dentistry | 2 | 11% |
Psychology | 1 | 5% |
Agricultural and Biological Sciences | 1 | 5% |
Other | 0 | 0% |
Unknown | 8 | 42% |