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Teratogenicity Testing

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Cover of 'Teratogenicity Testing'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 An Overview of Teratology
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    Chapter 2 Teratology Study Guidelines: An Overview
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    Chapter 3 Biological Concerns on the Selection of Animal Models for Teratogenic Testing
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    Chapter 4 The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
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    Chapter 5 Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
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    Chapter 6 Chick Embryonic Cardiomyocyte Micromass System for Assessing Developmental Cardiotoxicity of Drugs
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    Chapter 7 Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
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    Chapter 8 Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
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    Chapter 9 Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
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    Chapter 10 Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
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    Chapter 11 Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
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    Chapter 12 Effect of Teratogens on Development of Drosophila melanogaster
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    Chapter 13 Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
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    Chapter 14 Behavioral Teratogenesis in Drosophila melanogaster
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    Chapter 15 Evaluation of Teratogenicity of Pharmaceuticals Using FETAX
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    Chapter 16 Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
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    Chapter 17 Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis
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    Chapter 18 Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development
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    Chapter 19 General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol
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    Chapter 20 Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio)
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    Chapter 21 Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
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    Chapter 22 Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure
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    Chapter 23 Omics in Zebrafish Teratogenesis
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    Chapter 24 Proteomic Analysis of Zebrafish (Danio rerio) After Chemical Exposure
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    Chapter 25 Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio)
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    Chapter 26 Oxidative Stress Assessment in Zebrafish Larvae
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    Chapter 27 Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
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    Chapter 28 Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus
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    Chapter 29 Histological and Histochemical Profile for Teratological Assessment in Mus musculus
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    Chapter 30 In Vivo Analysis of Apoptosis in Embryonic Hippocampus
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    Chapter 31 Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus
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    Chapter 32 Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse
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    Chapter 33 Methodology of Genotoxic and Teratogenic Studies in Rats
  35. Altmetric Badge
    Chapter 34 Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos
Attention for Chapter 26: Oxidative Stress Assessment in Zebrafish Larvae
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Chapter title
Oxidative Stress Assessment in Zebrafish Larvae
Chapter number 26
Book title
Teratogenicity Testing
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7883-0_26
Pubmed ID
Book ISBNs
978-1-4939-7882-3, 978-1-4939-7883-0
Authors

Inês Domingues, Carlos Gravato, Domingues, Inês, Gravato, Carlos

Abstract

Chemical or environmental aggression often leads to oxidative stress and antioxidant responses in organisms in which are involved several components and enzymes. Catalase, glutathione-S-transferase, total glutathione and lipid peroxidation are key elements to understand the oxidative status of an organism and have been measured using spectrophotometric methods adapted to 96-well microtiter plates. In this work we describe the methodologies for analyses in pools of 96 h zebrafish (Danio rerio) embryos.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 7 23%
Student > Ph. D. Student 6 19%
Researcher 5 16%
Student > Doctoral Student 1 3%
Unspecified 1 3%
Other 2 6%
Unknown 9 29%
Readers by discipline Count As %
Environmental Science 5 16%
Agricultural and Biological Sciences 4 13%
Biochemistry, Genetics and Molecular Biology 4 13%
Unspecified 1 3%
Arts and Humanities 1 3%
Other 3 10%
Unknown 13 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 July 2018.
All research outputs
#18,641,800
of 23,094,276 outputs
Outputs from Methods in molecular biology
#7,988
of 13,208 outputs
Outputs of similar age
#330,872
of 442,658 outputs
Outputs of similar age from Methods in molecular biology
#950
of 1,499 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,208 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1,499 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.