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Lung Innate Immunity and Inflammation

Overview of attention for book
Lung Innate Immunity and Inflammation
Springer New York

Table of Contents

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    Book Overview
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    Chapter 1 500 Million Alveoli from 30,000 Feet: A Brief Primer on Lung Anatomy
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    Chapter 2 Overview of Innate Lung Immunity and Inflammation
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    Chapter 3 Isolation and Characterization of Mononuclear Phagocytes in the Mouse Lung and Lymph Nodes
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    Chapter 4 Isolation and Characterization of Mouse Neutrophils
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    Chapter 5 Isolation and Characterization of Mouse Fibroblasts
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    Chapter 6 Isolation of Rat and Mouse Alveolar Type II Epithelial Cells
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    Chapter 7 Isolation and Characterization of Human Alveolar Type II Cells
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    Chapter 8 Air–Liquid Interface Culture of Human and Mouse Airway Epithelial Cells
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    Chapter 9 Isolation and Characterization of Human Lung Myeloid Cells
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    Chapter 10 Measurement of Protein Permeability and Fluid Transport of Human Alveolar Epithelial Type II Cells Under Pathological Conditions
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    Chapter 11 Measuring Innate Immune Function in Mouse Mononuclear Phagocytes
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    Chapter 12 Measuring Neutrophil Bactericidal Activity
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    Chapter 13 Modulation of Myeloid Cell Function Using Conditional and Inducible Transgenic Approaches
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    Chapter 14 Modulation of Lung Epithelial Cell Function Using Conditional and Inducible Transgenic Approaches
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    Chapter 15 Computational Analysis of RNA-Seq Data from Airway Epithelial Cells for Studying Lung Disease
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    Chapter 16 Application of Proteomics in Lung Research
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    Chapter 17 Application of Metabolomics in Lung Research
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    Chapter 18 Functional Genomics in Murine Macrophages
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    Chapter 19 Assessment of Ozone-Induced Lung Injury in Mice
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    Chapter 20 Lung Histological Methods
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    Chapter 21 Intravital Microscopy in the Mouse Lung
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    Chapter 22 Mouse Models of Acute Lung Injury and ARDS
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    Chapter 23 Mouse Models of Asthma
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    Chapter 24 Animal Models of Pulmonary Fibrosis
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    Chapter 25 Mouse Models of COPD
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    Chapter 26 Mouse Models of Viral Infection
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    Chapter 27 Delivery of Therapeutics to the Lung
Attention for Chapter 24: Animal Models of Pulmonary Fibrosis
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Chapter title
Animal Models of Pulmonary Fibrosis
Chapter number 24
Book title
Lung Innate Immunity and Inflammation
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-8570-8_24
Pubmed ID
Book ISBNs
978-1-4939-8569-2, 978-1-4939-8570-8
Authors

David N. O’Dwyer, Bethany B. Moore, O’Dwyer, David N., Moore, Bethany B.

Abstract

Pulmonary fibrosis is a debilitating disease and is often fatal. It may be the consequence of direct lung injury or the result of genetic defects and occupational, environmental, or drug-related exposures. In many cases the etiology is unknown. The pathogenesis of all forms of pulmonary fibrosis regardless of type of injury or etiology is incompletely understood. These disorders are characterized by the accumulation of extracellular matrix in the lung interstitium with a loss of lung compliance and impaired gas exchange that ultimately leads to respiratory failure. Animal models of pulmonary fibrosis have become indispensable in the improved understanding of these disorders. Multiple models have been developed each with advantages and disadvantages. In this chapter we discuss the application of two of the most commonly employed direct lung instillation models, namely, the induction of pulmonary fibrosis with bleomycin or fluorescein isothiocyanate (FITC). We provide details on design, materials, and methods and describe how these models can be best undertaken. We also discuss methods to induce fibrosis in aged mice using murine gamma-herpesvirus (γHV-68) and approaches to exacerbate bleomycin- or FITC-induced fibrosis using γHV-68.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 17%
Student > Master 5 12%
Researcher 4 10%
Student > Ph. D. Student 4 10%
Professor 2 5%
Other 5 12%
Unknown 14 34%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 20%
Agricultural and Biological Sciences 5 12%
Pharmacology, Toxicology and Pharmaceutical Science 4 10%
Immunology and Microbiology 4 10%
Medicine and Dentistry 3 7%
Other 5 12%
Unknown 12 29%