Chapter title |
Effects of Low-Level Laser Therapy in Autism Spectrum Disorder
|
---|---|
Chapter number | 234 |
Book title |
Clinical Medicine Research
|
Published in |
Advances in experimental medicine and biology, June 2018
|
DOI | 10.1007/5584_2018_234 |
Pubmed ID | |
Book ISBNs |
978-3-03-004836-5, 978-3-03-004837-2
|
Authors |
Gerry Leisman, Calixto Machado, Yanin Machado, Mauricio Chinchilla-Acosta, Leisman, Gerry, Machado, Calixto, Machado, Yanin, Chinchilla-Acosta, Mauricio |
Abstract |
The study examined the efficacy of low-level laser therapy, a form of photobiomodulation, for the treatment of irritability associated with autistic spectrum disorder in children and adolescents aged 5-17 years. Twenty-one of the 40 participants received eight 5-min procedures administered to the base of the skull and temporal areas across a 4-week period (test, i.e., active treatment participants). All the participants were evaluated with the Aberrant Behavior Checklist (ABC), with the global scale and five subscales (irritability/agitation, lethargy/social withdrawal, stereotypic behavior, hyperactivity/noncompliance, and inappropriate speech), and the Clinical Global Impressions (CGI) Scale including a severity-of-illness scale (CGI-S) and a global improvement/change scale (CGI-C). The evaluation took place at baseline, week 2 (interim), week 4 (endpoint), and week 8 (post-procedure) of the study. The adjusted mean difference in the baseline to study endpoint change in the ABC irritability subscale score between test and placebo participants was -15.17 in favor of the test procedure group. ANCOVA analysis found this difference to be statistically significant (F = 99.34, p < 0.0001) compared to the baseline ABC irritability subscale score. The study found that low-level laser therapy could be an effective tool for reducing irritability and other symptoms and behaviors associated with the autistic spectrum disorder in children and adolescents, with positive changes maintained and augmented over time. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 15 | 18% |
United States | 11 | 13% |
Canada | 5 | 6% |
Mexico | 2 | 2% |
New Zealand | 1 | 1% |
Ireland | 1 | 1% |
Sweden | 1 | 1% |
Netherlands | 1 | 1% |
Australia | 1 | 1% |
Other | 2 | 2% |
Unknown | 42 | 51% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 72 | 88% |
Scientists | 7 | 9% |
Science communicators (journalists, bloggers, editors) | 2 | 2% |
Practitioners (doctors, other healthcare professionals) | 1 | 1% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 70 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 10 | 14% |
Student > Bachelor | 8 | 11% |
Student > Doctoral Student | 6 | 9% |
Student > Master | 6 | 9% |
Student > Ph. D. Student | 5 | 7% |
Other | 9 | 13% |
Unknown | 26 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 12 | 17% |
Neuroscience | 10 | 14% |
Psychology | 6 | 9% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Physics and Astronomy | 2 | 3% |
Other | 10 | 14% |
Unknown | 27 | 39% |