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Teratogenicity Testing

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Cover of 'Teratogenicity Testing'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 An Overview of Teratology
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    Chapter 2 Teratology Study Guidelines: An Overview
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    Chapter 3 Biological Concerns on the Selection of Animal Models for Teratogenic Testing
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    Chapter 4 The Validated Embryonic Stem Cell Test with Murine Embryonic Stem Cells
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    Chapter 5 Human Pluripotent Stem Cells to Assess Developmental Toxicity in the Osteogenic Lineage
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    Chapter 6 Chick Embryonic Cardiomyocyte Micromass System for Assessing Developmental Cardiotoxicity of Drugs
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    Chapter 7 Flow Cytometry to Evaluate Potential Developmental Toxicants in the Embryonic Stem Cell
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    Chapter 8 Morphology-Based Whole Embryo Culture for Developmental Toxicity of Drugs
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    Chapter 9 Western Blot Methodologies for Analysis of In Vitro Protein Expression Induced by Teratogenic Agents
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    Chapter 10 Manipulation of MicroRNAs in Cultured Mouse Embryos: Applications for Developmental Toxicology
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    Chapter 11 Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
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    Chapter 12 Effect of Teratogens on Development of Drosophila melanogaster
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    Chapter 13 Cellular Responses in Drosophila melanogaster Following Teratogen Exposure
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    Chapter 14 Behavioral Teratogenesis in Drosophila melanogaster
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    Chapter 15 Evaluation of Teratogenicity of Pharmaceuticals Using FETAX
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    Chapter 16 Histological Observation of Teratogenic Phenotypes Induced in Frog Embryo Assays
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    Chapter 17 Visualization of Gene Expression Patterns by In Situ Hybridization on Early Stages of Development of Xenopus laevis
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    Chapter 18 Analysis of Lethality and Malformations During Zebrafish (Danio rerio) Development
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    Chapter 19 General Whole-Mount Immunohistochemistry of Zebrafish (Danio rerio) Embryos and Larvae Protocol
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    Chapter 20 Geometric Morphometrics as a Tool to Evaluate Teratogenic Effects in Zebrafish (Danio rerio)
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    Chapter 21 Live Metabolic Profile Analysis of Zebrafish Embryos Using a Seahorse XF 24 Extracellular Flux Analyzer
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    Chapter 22 Behavioral Profiling of Zebrafish (Danio rerio) Larvae Following Teratogen Exposure
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    Chapter 23 Omics in Zebrafish Teratogenesis
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    Chapter 24 Proteomic Analysis of Zebrafish (Danio rerio) After Chemical Exposure
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    Chapter 25 Immunohistochemical Assessment as a Tool for Investigating Developmental Toxicity in Zebrafish (Danio rerio)
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    Chapter 26 Oxidative Stress Assessment in Zebrafish Larvae
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    Chapter 27 Hemodynamic Studies for Analyzing the Teratogenic Effects of Drugs in the Zebrafish Embryo
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    Chapter 28 Western Blot Analysis and Immunostaining for Prediction of Embryotoxicity in Mus musculus
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    Chapter 29 Histological and Histochemical Profile for Teratological Assessment in Mus musculus
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    Chapter 30 In Vivo Analysis of Apoptosis in Embryonic Hippocampus
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    Chapter 31 Measurement of Mitochondrial Toxicity Parameters in Embryonic Hippocampus
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    Chapter 32 Animal Tests for Evaluation of Cognitive Impairment in Neonatal Mouse
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    Chapter 33 Methodology of Genotoxic and Teratogenic Studies in Rats
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    Chapter 34 Whole Mount In Situ Hybridization and Morphometric Analysis in Rabbit Embryos
Attention for Chapter 11: Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
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Chapter title
Insights into the Phenotypic and Behavioral Effects of Teratogenic Drugs in Caenorhabditis elegans
Chapter number 11
Book title
Teratogenicity Testing
Published in
Methods in molecular biology, January 2018
DOI 10.1007/978-1-4939-7883-0_11
Pubmed ID
Book ISBNs
978-1-4939-7882-3, 978-1-4939-7883-0
Authors

Caralina Marín de Evsikova, Marín de Evsikova, Caralina

Abstract

Environmental toxicants, chemical substances produced or introduced into the environment directly by humans or their activities, can act as teratogens during development that negatively impact health. Long-term ramifications of environmental exposures to sublethal doses of teratogens are often unrecognized and unknown. The round worm, Caenorhabditis elegans, is an emerging model organism to investigate the long-term impacts of environmental teratogens upon health. This chapter describes a toxicant exposure paradigm integrated with phenotyping assays to screen adult worms, and their progeny, for effects on reproduction, growth and development, behavior, and energy balance.

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Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2019.
All research outputs
#6,605,117
of 24,677,985 outputs
Outputs from Methods in molecular biology
#1,940
of 13,873 outputs
Outputs of similar age
#124,526
of 452,870 outputs
Outputs of similar age from Methods in molecular biology
#161
of 1,486 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 13,873 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 452,870 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 1,486 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.