Chapter title |
Generation of Transplantable Retinal Pigmented Epithelial (RPE) Cells for Treatment of Age-Related Macular Degeneration (AMD)
|
---|---|
Chapter number | 140 |
Book title |
Stem Cells and Aging
|
Published in |
Methods in molecular biology, June 2018
|
DOI | 10.1007/7651_2018_140 |
Pubmed ID | |
Book ISBNs |
978-1-4939-9712-1, 978-1-4939-9713-8
|
Authors |
Harshini Surendran, Reena J. Rathod, Rajarshi Pal, Surendran, Harshini, Rathod, Reena J., Pal, Rajarshi |
Abstract |
Age-related macular degeneration (AMD) is the foremost cause of blindness in people over the age of 60 worldwide. Clinically, this disease starts with distortion in central vision eventually leading to legal blindness. Vision loss has a significant impact on quality of life and incurs a substantial cost to the economy. Furthermore, AMD is a complex and progressive neurodegenerative disorder that triggers visual impairment due to the loss of retinal pigmented epithelium (RPE) and the light-sensitive photoreceptors that they support, protect and provide nutrition. Currently, there is no curative treatment for the most common form of this disease, i.e., dry AMD. A novel approach to treat AMD involves the transplantation of RPE cells derived from human induced pluripotent stem cells (iPSCs) in the outer retina. These iPSC-derived RPE cells not only show characteristics similar to native RPE but also could replace as well as regenerate damaged pathologic RPE and produce supportive growth factors and cytokines. Several clinical trials are being conducted taking advantage of a variety of cell- and tissue engineering-based approaches. Here, we present a simple, cost effective, and scalable cell-culture model for generation of purified RPE thus providing the foundation for developing an allogeneic cell therapy for AMD. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 6 | 60% |
Unknown | 4 | 40% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 8 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 35 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 6 | 17% |
Student > Ph. D. Student | 4 | 11% |
Student > Postgraduate | 3 | 9% |
Student > Master | 3 | 9% |
Unspecified | 2 | 6% |
Other | 4 | 11% |
Unknown | 13 | 37% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 17% |
Biochemistry, Genetics and Molecular Biology | 4 | 11% |
Agricultural and Biological Sciences | 3 | 9% |
Unspecified | 2 | 6% |
Psychology | 2 | 6% |
Other | 1 | 3% |
Unknown | 17 | 49% |