Article
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Mendeley readers
Attention Score in Context
| Chapter title |
Neurotoxic Ca2+ Signaling Induced by Amyloid–β Oligomers in Aged Hippocampal Neurons In Vitro
|
|---|---|
| Book title |
Amyloid Proteins
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-7816-8_20 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-7815-1, 978-1-4939-7816-8
|
| Authors |
Lucía Núñez, María Calvo-Rodríguez, Erica Caballero, Mónica García-Durillo, Carlos Villalobos |
| Abstract |
Alzheimer's disease (AD), the most prevalent dementia linked to aging, involves neurotoxic effects of amyloid β species and dishomeostasis of intracellular Ca2+. To investigate mechanisms of AD, the effects of soluble species of amyloid β oligomers (Aβo) prepared in medium devoid of glutamate receptor agonists can be tested on intracellular Ca2+ in long-term cultures of rat hippocampal neurons that reflect aging neurons. Furthermore, changes in expression of proteins involved in oligomer responses and AD can be tested in the same neurons using quantitative immunofluorescence. Detailed procedures for the preparation of Aβ species in defined medium, long-term culture of rat hippocampal neurons mimicking aged neurons, calcium imaging and quantitative immunofluorescence in these cultures are described in this chapter. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 2 | 25% |
| Other | 2 | 25% |
| Professor > Associate Professor | 1 | 13% |
| Unspecified | 1 | 13% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 13% |
| Environmental Science | 1 | 13% |
| Economics, Econometrics and Finance | 1 | 13% |
| Neuroscience | 1 | 13% |
| Medicine and Dentistry | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 3 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2018.
All research outputs
#4,240,790
of 23,090,520 outputs
Outputs from Methods in molecular biology
#1,141
of 13,206 outputs
Outputs of similar age
#92,900
of 442,634 outputs
Outputs of similar age from Methods in molecular biology
#95
of 1,499 outputs
Altmetric has tracked 23,090,520 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,206 research outputs from this source. They receive a mean Attention Score of 3.4. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 442,634 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 77% of its contemporaries.
We're also able to compare this research output to 1,499 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.