Chapter title |
Clinical efficacy of budipine in Parkinson's disease.
|
---|---|
Chapter number | 3 |
Book title |
Diagnosis and Treatment of Parkinson’s Disease — State of the Art
|
Published in |
Journal of neural transmission Supplementum, January 1999
|
DOI | 10.1007/978-3-7091-6360-3_3 |
Pubmed ID | |
Book ISBNs |
978-3-21-183275-2, 978-3-70-916360-3
|
Authors |
Professor Dr. H. Przuntek, T. Müller, H. Przuntek, Przuntek, H., Müller, T. |
Abstract |
The lipophilic t-butyl analog of 1-alkyl-4,4-diphenyl piperidine, budipine, possesses a polyvalent spectrum of mechanisms of action. Budipine experimentally increased the brain content of norepinephrine, serotonine, dopamine and histamine in reserpine treated rats. Budipine did not alter the receptor affinity of these neurotransmitters but antagonizes the effect of NMDA at its receptor binding site in vitro. Budipine reduced MPP+ toxicity in the nigrostriatal system of mice. This complex pharmacologic profile is not comparable to the one of convenient antiparkinsonian drugs. In clinical trials budipine reduced tremor, akinesia and rigidity. Budipine induced a relevant additional positive effect in patients with an optimal dopaminergic therapy based on levodopa and dopamine agonists, such as bromocriptine. Current available data suggest that the need for levodopa application in early stages of the disease may be postponed by budipine and that the long-term application of budipine may induce a levodopa-sparing effect. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 7 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 2 | 29% |
Student > Bachelor | 1 | 14% |
Other | 1 | 14% |
Student > Master | 1 | 14% |
Unknown | 2 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 2 | 29% |
Neuroscience | 1 | 14% |
Medicine and Dentistry | 1 | 14% |
Unknown | 3 | 43% |