Chapter title |
Biflavonoids as Potential Small Molecule Therapeutics for Alzheimer's Disease.
|
---|---|
Chapter number | 3 |
Book title |
Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-3-319-18365-7_3 |
Pubmed ID | |
Book ISBNs |
978-3-31-918364-0, 978-3-31-918365-7
|
Authors |
Thapa, Arjun, Chi, Eva Y, Arjun Thapa, Eva Y. Chi Ph.D., Eva Y. Chi |
Editors |
Neville Vassallo |
Abstract |
Flavonoids are naturally occurring phytochemicals found in a variety of fruits and vegetables and offer color, flavor, aroma, nutritional and health benefits. Flavonoids have been found to play a neuroprotective role by inhibiting and/or modifying the self-assembly of the amyloid-β (Aβ) peptide into oligomers and fibrils, which are linked to the pathogenesis of Alzheimer's disease. The neuroprotective efficacy of flavonoids has been found to strongly depend on their structure and functional groups. Flavonoids may exist in monomeric, as well as di-, tri-, tetra- or polymeric form through C-C or C-O-C linkages. It has been shown that flavonoids containing two or more units, e.g., biflavonoids, exert greater biological activity than their respective monoflavonoids. For instance, biflavonoids have the ability to distinctly alter Aβ aggregation and more effectively reduce the toxicity of Aβ oligomers compared to the monoflavonoid moieties. Although the molecular mechanisms remain to be elucidated, flavonoids have been shown to alter the Aβ aggregation pathway to yield non-toxic, unstructured Aβ aggregates, as well as directly exerting a neuroprotective effect to cells. In this chapter, we review biflavonoid-mediated Aβ aggregation and toxicity, and highlight the beneficial roles biflavonoids can potentially play in the prevention and treatment of Alzheimer's disease. |
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Mendeley readers
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Unknown | 31 | 100% |
Demographic breakdown
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Student > Doctoral Student | 4 | 13% |
Student > Bachelor | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Researcher | 3 | 10% |
Student > Postgraduate | 2 | 6% |
Other | 4 | 13% |
Unknown | 12 | 39% |
Readers by discipline | Count | As % |
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Neuroscience | 4 | 13% |
Biochemistry, Genetics and Molecular Biology | 3 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 6% |
Chemistry | 2 | 6% |
Agricultural and Biological Sciences | 2 | 6% |
Other | 4 | 13% |
Unknown | 14 | 45% |