Chapter title |
Targeting miRNA for Therapy of Juvenile and Adult Diabetic Cardiomyopathy
|
---|---|
Book title |
Exosomes, Stem Cells and MicroRNA
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-74470-4_4 |
Pubmed ID | |
Book ISBNs |
978-3-31-974469-8, 978-3-31-974470-4
|
Authors |
Shyam Sundar Nandi, Paras Kumar Mishra |
Abstract |
Prevalence of diabetes mellitus (DM), a multifactorial disease often diagnosed with high blood glucose levels, is rapidly increasing in the world. Association of DM with multi-organ dysfunction including cardiomyopathy makes it a leading cause of morbidity and mortality. There are two major types of DM: type 1 DM (T1D) and type 2 DM (T2D). T1D is diagnosed by reduced levels of insulin and high levels of glucose in the blood. It is caused due to pancreatic beta cell destruction/loss, and mostly found in juveniles (juvenile DM). T2D is diagnosed by increased levels of insulin and glucose in the blood. It is caused due to insulin receptor dysfunction, and mostly found in the adults (adult DM). Both T1D and T2D impair cardiac muscle function, which is referred to as diabetic cardiomyopathy. We and others have reported that miRNAs, a novel class of tiny non-coding regulatory RNAs, are differentially expressed in the diabetic heart and they contribute to diabetic cardiomyopathy. Here, we elaborated the biogenesis of miRNA, how miRNA regulates a gene, cardioprotective roles of different miRNAs including miRNAs present in exosomes, underlying molecular mechanisms by which miRNA ameliorates diabetic cardiomyopathy, and the role of miRNA as a potential therapeutic target for juvenile and adult diabetic cardiomyopathy. |
X Demographics
Geographical breakdown
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United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 43 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 14% |
Student > Master | 5 | 12% |
Researcher | 5 | 12% |
Student > Bachelor | 4 | 9% |
Student > Postgraduate | 2 | 5% |
Other | 3 | 7% |
Unknown | 18 | 42% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 10 | 23% |
Medicine and Dentistry | 5 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
Immunology and Microbiology | 1 | 2% |
Nursing and Health Professions | 1 | 2% |
Other | 2 | 5% |
Unknown | 22 | 51% |