| Chapter title |
Helminthic therapy: using worms to treat immune-mediated disease.
|
|---|---|
| Chapter number | 12 |
| Book title |
Pathogen-Derived Immunomodulatory Molecules
|
| Published in |
Advances in experimental medicine and biology, January 2010
|
| DOI | 10.1007/978-1-4419-1601-3_12 |
| Pubmed ID | |
| Book ISBNs |
978-1-4419-1600-6, 978-1-4419-1601-3
|
| Authors |
David E. Elliott, Joel V. Weinstock, Elliott, David E., Weinstock, Joel V. |
| Abstract |
There is an epidemic of immune-mediated disease in highly-developed industrialized countries. Such diseases, like inflammatory bowel disease, multiple sclerosis and asthma increase in prevalence as populations adopt modern hygienic practices. These practices prevent exposure to parasitic worms (helminths). Epidemiologic studies suggest that people who carry helminths have less immune-mediated disease. Mice colonized with helminths are protected from disease in models of colitis, encephalitis, Type 1 diabetes and asthma. Clinical trials show that exposure to helminths reduce disease activity in patients with ulcerative colitis or Crohn's disease. This chapter reviews some of the work showing that colonization with helminths alters immune responses, against dysregulated inflammation. These helminth-host immune interactions have potentially important implications for the treatment of immune-mediated diseases. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Israel | 1 | 2% |
| Spain | 1 | 2% |
| United States | 1 | 2% |
| Tanzania, United Republic of | 1 | 2% |
| Unknown | 61 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 17 | 26% |
| Student > Ph. D. Student | 12 | 18% |
| Researcher | 7 | 11% |
| Student > Master | 6 | 9% |
| Professor | 4 | 6% |
| Other | 7 | 11% |
| Unknown | 12 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 40% |
| Medicine and Dentistry | 12 | 18% |
| Biochemistry, Genetics and Molecular Biology | 4 | 6% |
| Social Sciences | 2 | 3% |
| Immunology and Microbiology | 2 | 3% |
| Other | 7 | 11% |
| Unknown | 12 | 18% |