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Natural Killer Cells

Overview of attention for book
Attention for Chapter 446: NK Cells and Cancer Immunoediting.
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Chapter title
NK Cells and Cancer Immunoediting.
Chapter number 446
Book title
Natural Killer Cells
Published in
Current topics in microbiology and immunology, May 2015
DOI 10.1007/82_2015_446
Pubmed ID
Book ISBNs
978-3-31-923915-6, 978-3-31-923916-3
Authors

Guillerey, Camille, Smyth, Mark J, Camille Guillerey, Mark J. Smyth, Smyth, Mark J.

Abstract

Natural killer (NK) cells are innate lymphoid cells (ILC) known for their ability to recognize and rapidly eliminate infected or transformed cells. Consequently, NK cells are fundamental for host protection against virus infections and malignancies. Even though the critical role of NK cells in cancer immunosurveillance was suspected years ago, the underlying mechanisms took time to be unraveled. Today, it is clear that anti-tumor functions of NK cells are tightly regulated and expand far beyond the simple killing of malignant cells. In spite of tremendous steps made in understanding the NK cell biology, further work is warranted to fully exploit the anticancer potential of these cells. Indeed, tumor-mediated immune suppression hampers NK cell activity, thus complicating their stimulation for therapeutic purposes. Herein, we review the current knowledge of NK cell functions in anti-tumor immunity . We discuss NK cell activity in the cancer immunoediting process with particular emphasis on the elimination and escape phases.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 71 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 71 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 31%
Student > Master 11 15%
Student > Bachelor 6 8%
Student > Doctoral Student 4 6%
Researcher 4 6%
Other 5 7%
Unknown 19 27%
Readers by discipline Count As %
Immunology and Microbiology 19 27%
Biochemistry, Genetics and Molecular Biology 15 21%
Agricultural and Biological Sciences 6 8%
Medicine and Dentistry 6 8%
Engineering 2 3%
Other 5 7%
Unknown 18 25%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2015.
All research outputs
#17,874,146
of 26,184,649 outputs
Outputs from Current topics in microbiology and immunology
#480
of 715 outputs
Outputs of similar age
#170,675
of 282,368 outputs
Outputs of similar age from Current topics in microbiology and immunology
#8
of 9 outputs
Altmetric has tracked 26,184,649 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 715 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.1. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 282,368 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 9 others from the same source and published within six weeks on either side of this one.