| Chapter title |
Host Range Restricted, Non-Replicating Vaccinia Virus Vectors as Vaccine Candidates
|
|---|---|
| Chapter number | 2 |
| Book title |
Novel Strategies in the Design and Production of Vaccines
|
| Published in |
Advances in experimental medicine and biology, January 1996
|
| DOI | 10.1007/978-1-4899-1382-1_2 |
| Pubmed ID | |
| Book ISBNs |
978-1-4899-1384-5, 978-1-4899-1382-1
|
| Authors |
Bernard Moss, Miles W. Carroll, Linda S. Wyatt, Jack R. Bennink, Vanessa M. Hirsch, Simoy Goldstein, William R. Elkins, Thomas R. Fuerst, Jeffrey D. Lifson, M. Piatak, Nicholas P. Restifo, Willem Overwijk, Ronald Chamberlain, Steven A. Rosenberg, Gerd Sutter, Moss, Bernard, Carroll, Miles W., Wyatt, Linda S., Bennink, Jack R., Hirsch, Vanessa M., Goldstein, Simoy, Elkins, William R., Fuerst, Thomas R., Lifson, Jeffrey D., Piatak, M., Restifo, Nicholas P., Overwijk, Willem, Chamberlain, Ronald, Rosenberg, Steven A., Sutter, Gerd |
| Abstract |
Three model systems were used to demonstrate the immunogenicity of highly attenuated and replication-defective recombinant MVA. (1) Intramuscular inoculation of MVA-IN-Fha/np induced humoral and cell-mediated immune responses in mice and protectively immunized them against a lethal respiratory challenge with influenza virus. Intranasal vaccination was also protective, although higher doses were needed. (2) In rhesus macaques, an immunization scheme involving intramuscular injections of MVA-SIVenv/gag/pol greatly reduced the severity of disease caused by an SIV challenge. (3) In a murine cancer model, immunization with MVA-beta gal prevented the establishment of tumor metastases and even prolonged life in animals with established tumors. These results, together with previous data on the safety of MVA in humans, suggest the potential usefulness of recombinant MVA for prophylactic vaccination and therapeutic treatment of infectious diseases and cancer. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Argentina | 1 | 3% |
| Unknown | 34 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 26% |
| Professor > Associate Professor | 5 | 14% |
| Student > Ph. D. Student | 5 | 14% |
| Student > Doctoral Student | 3 | 9% |
| Student > Bachelor | 3 | 9% |
| Other | 6 | 17% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 13 | 37% |
| Immunology and Microbiology | 6 | 17% |
| Biochemistry, Genetics and Molecular Biology | 6 | 17% |
| Medicine and Dentistry | 5 | 14% |
| Environmental Science | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 3 | 9% |