Chapter title |
Cardiac MRI in Small Animals
|
---|---|
Chapter number | 16 |
Book title |
Preclinical MRI
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7531-0_16 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7530-3, 978-1-4939-7531-0
|
Authors |
Min-Chi Ku, Till Huelnhagen, Thoralf Niendorf, Andreas Pohlmann, Ku, Min-Chi, Huelnhagen, Till, Niendorf, Thoralf, Pohlmann, Andreas |
Abstract |
Cardiac magnetic resonance (MR) imaging of mice is a valuable tool for the precise in vivo diagnosis and prognosis of heart defects. This detailed protocol describes the method of cardiac MR imaging in mice step by step. A series of MR images captures the contractile function of the mouse heart and post-processing of the image data yields morphometric parameters (myocardial mass, myocardial wall thickness, ventricular end-systolic and end-diastolic volume) as well as functional parameters (stroke volume and ejection fraction). This protocol may also serve as a starting point for MR imaging of rats, by using larger image dimensions (field-of-view) and MR hardware suitable for larger animals. |
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