| Chapter title |
Rab family of GTPases.
|
|---|---|
| Chapter number | 1 |
| Book title |
Rab GTPases
|
| Published in |
Methods in molecular biology, January 2015
|
| DOI | 10.1007/978-1-4939-2569-8_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-2568-1, 978-1-4939-2569-8
|
| Authors |
Guangpu Li, M Caleb Marlin, M. Caleb Marlin, Li, Guangpu, Marlin, M. Caleb |
| Abstract |
Rab proteins represent the largest branch of the Ras-like small GTPase superfamily and there are 66 Rab genes in the human genome. They alternate between GTP- and GDP-bound states, which are facilitated by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and function as molecular switches in regulation of intracellular membrane trafficking in all eukaryotic cells. Each Rab targets to an organelle and specify a transport step along exocytic, endocytic, and recycling pathways as well as the crosstalk between these pathways. Through interactions with multiple effectors temporally, a Rab can control membrane budding and formation of transport vesicles, vesicle movement along cytoskeleton, and membrane fusion at the target compartment. The large number of Rab proteins reflects the complexity of the intracellular transport system, which is essential for the localization and function of membrane and secretory proteins such as hormones, growth factors, and their membrane receptors. As such, Rab proteins have emerged as important regulators for signal transduction, cell growth, and differentiation. Altered Rab expression and/or activity have been implicated in diseases ranging from neurological disorders, diabetes to cancer. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 129 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 26 | 20% |
| Student > Bachelor | 18 | 14% |
| Student > Master | 14 | 11% |
| Researcher | 12 | 9% |
| Other | 7 | 5% |
| Other | 10 | 8% |
| Unknown | 42 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 44 | 34% |
| Agricultural and Biological Sciences | 15 | 12% |
| Medicine and Dentistry | 6 | 5% |
| Immunology and Microbiology | 6 | 5% |
| Neuroscience | 5 | 4% |
| Other | 9 | 7% |
| Unknown | 44 | 34% |