Chapter title |
Th1/Th2 Immune Balance and Other T Helper Subsets in IgG4-Related Disease
|
---|---|
Chapter number | 40 |
Book title |
IgG4-Related Disease
|
Published in |
Current topics in microbiology and immunology, January 2016
|
DOI | 10.1007/82_2016_40 |
Pubmed ID | |
Book ISBNs |
978-3-31-952541-9, 978-3-31-952542-6
|
Authors |
Masafumi Moriyama, Seiji Nakamura, Moriyama, Masafumi, Nakamura, Seiji |
Abstract |
IgG4-related disease (IgG4-RD) is a systemic disease characterized by elevated serum IgG4 levels and a strong infiltration of IgG4-positive plasma cells in various organs. IgG4-RD patients also frequently suffer from allergic diseases, including asthma and atopic dermatitis. It is well known that T helper type 2 (Th2) cells have an important role in the initiation of allergic diseases, and Th2 cytokines such as interleukin (IL)-4 and IL-13 promote class switching to IgG4. Therefore, IgG4-RD is considered to be a Th2-predominant disease. However, other Th subsets, including regulatory T cells and T follicular helper cells, have recently received increasing attention with regard to the pathogenesis of IgG4-RD. Exploring the interconnected network of Th subsets in IgG4-RD is a highly promising field of investigation. In this review, we focus on the localization and functions of individual Th subsets to clarify the involvement of these cells in the pathogenesis of IgG4-RD. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 8 | 27% |
Other | 5 | 17% |
Student > Master | 5 | 17% |
Student > Ph. D. Student | 4 | 13% |
Student > Bachelor | 2 | 7% |
Other | 3 | 10% |
Unknown | 3 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Immunology and Microbiology | 9 | 30% |
Medicine and Dentistry | 8 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 7% |
Biochemistry, Genetics and Molecular Biology | 2 | 7% |
Agricultural and Biological Sciences | 1 | 3% |
Other | 3 | 10% |
Unknown | 5 | 17% |