Chapter title |
The leptospiral outer membrane.
|
---|---|
Chapter number | 8 |
Book title |
Leptospira and Leptospirosis
|
Published in |
Current topics in microbiology and immunology, November 2014
|
DOI | 10.1007/978-3-662-45059-8_8 |
Pubmed ID | |
Book ISBNs |
978-3-66-245058-1, 978-3-66-245059-8
|
Authors |
Haake DA, Zückert WR, David A. Haake, Wolfram R. Zückert |
Abstract |
The outer membrane (OM) is the front line of leptospiral interactions with their environment and the mammalian host. Unlike most invasive spirochetes, pathogenic leptospires must be able to survive in both free-living and host-adapted states. As organisms move from one set of environmental conditions to another, the OM must cope with a series of conflicting challenges. For example, the OM must be porous enough to allow nutrient uptake, yet robust enough to defend the cell against noxious substances. In the host, the OM presents a surface decorated with adhesins and receptors for attaching to, and acquiring, desirable host molecules such as the complement regulator, Factor H.Factor H. On the other hand, the OM must enable leptospires to evade detection by the host's immune system on their way from sites of invasion through the bloodstream to the protected niche of the proximal tubule. The picture that is emerging of the leptospiral OM is that, while it shares many of the characteristics of the OMs of spirochetes and Gram-negative bacteria, it is also unique and different in ways that make it of general interest to microbiologists. For example, unlike most other pathogenic spirochetes, the leptospiral OM is rich in lipopolysaccharide (LPS). Leptospiral LPS is similar to that of Gram-negative bacteria but has a number of unique structural features that may explain why it is not recognized by the LPS-specific Toll-like receptor 4 of humans. As in other spirochetes, lipoproteins are major components of the leptospiral OM, though their roles are poorly understood. The functions of transmembrane outer membrane proteins (OMPs) in many cases are better understood, thanks to homologies with their Gram-negative counterparts and the emergence of improved genetic techniques. This chapter will review recent discoveries involving the leptospiral OM and its role in leptospiral physiology and pathogenesis. |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 128 | 100% |
Demographic breakdown
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Student > Bachelor | 19 | 15% |
Researcher | 17 | 13% |
Student > Ph. D. Student | 17 | 13% |
Student > Master | 13 | 10% |
Student > Doctoral Student | 7 | 5% |
Other | 18 | 14% |
Unknown | 37 | 29% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 19 | 15% |
Veterinary Science and Veterinary Medicine | 15 | 12% |
Immunology and Microbiology | 14 | 11% |
Agricultural and Biological Sciences | 13 | 10% |
Medicine and Dentistry | 9 | 7% |
Other | 12 | 9% |
Unknown | 46 | 36% |