| Chapter title |
Targeted Immunotherapy Designed to Treat MUC1-Expressing Solid Tumour.
|
|---|---|
| Chapter number | 429 |
| Book title |
Cancer Vaccines
|
| Published in |
Current topics in microbiology and immunology, February 2015
|
| DOI | 10.1007/82_2015_429 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-923909-5, 978-3-31-923910-1
|
| Authors |
Bruce Acres, Gisele Lacoste, Jean-Marc Limacher, Acres, Bruce, Lacoste, Gisele, Limacher, Jean-Marc |
| Abstract |
Several approaches to antigen-specific immunotherapy of cancer antigen-specific immunotherapy of cancerantigen-specific immunotherapy of cancer have been tested clinically. In this chapter, we will describe studies done with the antigen MUC1. Tested MUC1 therapeutic vaccinesMUC1 therapeutic vaccines include the following: monoclonal antibodies (MAbs) specific for MUC1; synthetic and recombinant polypeptides from the protein sequence of MUC1; dendritic cells carrying MUC1; RNA and DNA vaccinations; and recombinant viruses carrying the MUC1 DNA sequence. Chemotherapy of cancer aims to be toxic to the cancer cells with manageable side effects to the patient. In contrast, antigen-specific immunotherapy of cancer aims to treat the patient, such that the patient is then able to control and eventually eliminate their cancer cells. It is therefore important to know the immune statusimmune status of each cancer patientcancer patient prior to therapy. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Korea, Democratic People's Republic of | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 67% |
| Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 12 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 25% |
| Student > Postgraduate | 2 | 17% |
| Researcher | 2 | 17% |
| Professor | 1 | 8% |
| Student > Bachelor | 1 | 8% |
| Other | 0 | 0% |
| Unknown | 3 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 25% |
| Chemistry | 2 | 17% |
| Nursing and Health Professions | 1 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
| Medicine and Dentistry | 1 | 8% |
| Other | 1 | 8% |
| Unknown | 3 | 25% |