Chapter title |
Primary Hyperparathyroidism in MEN2 Syndromes
|
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Chapter number | 8 |
Book title |
Medullary Thyroid Carcinoma
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2015
|
DOI | 10.1007/978-3-319-22542-5_8 |
Pubmed ID | |
Book ISBNs |
978-3-31-922541-8, 978-3-31-922542-5
|
Authors |
Maria Alevizaki, Katerina Saltiki, Alevizaki, Maria, Saltiki, Katerina |
Abstract |
One of the components of trethe classical form of MEN2 syndromes is primary hyperparathyroidism (PHP). It occurs in 20-30 % of the typical MEN2A syndrome. The prevalence is more rare in gene carriers as these frequently have familial MTC only. PHP is diagnosed more frequently in association with the exon 11, codon 634 mutation of the ret gene-so there is phenotype/genotype correlation. The clinical manifestations of PHP in MEN2 are usually mild and the peak age of diagnosis after the 3rd decade. The treatment is surgical excision of the enlarged gland(s). Although there can be multigland disease in the parathyroids, it is frequently the case that both hyperplasia and adenoma may coexist, or even a single adenoma may be found during the investigation and finally during the operation. Patients with MEN2 syndromes should be screened for PHP with serum calcium measurements. The intensity of the screening should be higher in those carrying the ret mutations most frequently associated with this manifestation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 24 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Bachelor | 5 | 21% |
Other | 4 | 17% |
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Professor | 3 | 13% |
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Other | 2 | 8% |
Unknown | 3 | 13% |
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Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Unknown | 5 | 21% |