Chapter title |
Does Stress Elicit Depression? Evidence From Clinical and Preclinical Studies
|
---|---|
Chapter number | 292 |
Book title |
Behavioral Neurobiology of Stress-related Disorders
|
Published in |
Current topics in behavioral neurosciences, March 2014
|
DOI | 10.1007/7854_2014_292 |
Pubmed ID | |
Book ISBNs |
978-3-66-245125-0, 978-3-66-245126-7
|
Authors |
Helle M. Sickmann, Yan Li, Arne Mørk, Connie Sanchez, Maria Gulinello, Sickmann, Helle M., Li, Yan, Mørk, Arne, Sanchez, Connie, Gulinello, Maria |
Abstract |
Exposure to stressful situations may induce or deteriorate an already existing depression. Stress-related depression can be elicited at an adolescent/adult age but evidence also shows that early adverse experiences even at the fetal stage may predispose the offspring for later development of depression. The hypothalamus-pituitary-adrenal axis (HPA-axis) plays a key role in regulating the stress response and dysregulation in the system has been linked to depression both in humans and in animal models. This chapter critically reviews clinical and preclinical findings that may explain how stress can cause depression, including HPA-axis changes and alterations beyond the HPA-axis. As stress does not elicit depression in the majority of the population, this motivated research to focus on understanding the biology underlying resilient versus sensitive subjects. Animal models of depression have contributed to a deeper understanding of these mechanisms. Findings from these models will be presented. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 44 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 8 | 18% |
Student > Master | 8 | 18% |
Student > Ph. D. Student | 8 | 18% |
Student > Doctoral Student | 5 | 11% |
Other | 2 | 5% |
Other | 4 | 9% |
Unknown | 9 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 11 | 25% |
Agricultural and Biological Sciences | 5 | 11% |
Medicine and Dentistry | 4 | 9% |
Neuroscience | 4 | 9% |
Social Sciences | 2 | 5% |
Other | 6 | 14% |
Unknown | 12 | 27% |