Proteases as Targets for Therapy

Chapter 2 Clinical Experience with Human Immunodeficiency Virus Protease Inhibitors: Antiretroviral Results, Questions and Future Strategies

Chapter 3 The Nature of Resistance to Human Immunodeficiency Virus Type-1 Protease Inhibitors

Chapter 4 The Next Generation of Human Immunodeficiency Virus Protease Inhibitors: Targeting Viral Resistance

Chapter 5 The Proteinases Encoded by Hepatitis C Virus as Therapeutic Targets

Chapter 6 The Human Herpes-Virus Proteases

Chapter 7 The 3C Proteinases of Picornaviruses and Other Positive-Sense, Single-Stranded RNA Viruses

Chapter 8 Adenovirus Proteinase-Antiviral Target for Triple-Combination Therapy on a Single Enzyme: Potential Inhibitor-Binding Sites

Chapter 9 Proteinases as Virulence Factors in Bacterial Diseases and as Potential Targets for Therapeutic Intervention with Proteinase Inhibitors

Chapter 10 Parasite Proteases as Targets for Therapy

Chapter 11 Host Proteinases as Targets for Therapeutic Intervention

Chapter 12 The Role of Metalloprotease Inhibitors in Cancer and Chronic Inflammatory Diseases

Chapter 13 The Tumor Necrosis Factor-α Converting Enzyme

Chapter 14 Serine Elastases in Inflammatory and Vascular Diseases

Chapter 15 Inhibitors of Thrombin and Factor Xa

Chapter 16 Inhibitors of Papain-Like Cysteine Peptidases in Cancer

Chapter 17 Caspases and Their Natural Inhibitors as Therapeutic Targets for Regulating Apoptosis

Chapter 18 Proteasome and Apoptosis

Chapter 19 Proteolytic Processing of the Amyloid Precursor Protein of Alzheimer’s Disease

Chapter 20 Presenilins and β-Amyloid Precursor Protein-Proteolytically Processed Proteins Involved in the Generation of Alzheimer’s Amyloid β Peptide