| Chapter title |
Design and synthesis of beta-peptides with biological activity.
|
|---|---|
| Book title |
Protein Design
|
| Published in |
Methods in molecular biology, December 2005
|
| DOI | 10.1385/1-59745-116-9:95 |
| Pubmed ID | |
| Book ISBNs |
978-1-58829-585-9, 978-1-59745-116-1
|
| Authors |
Marc J. Koyack, Richard P. Cheng, Koyack, Marc J., Cheng, Richard P. |
| Abstract |
beta-Peptides have been used as a platform for developing bioactive compounds with various types of bioactivity such as antimicrobial activity, cholesterol absorption inhibition, somatostatin receptor agonist, and hDM2 inhibition. These bioactive beta-peptides have been designed based on bioactive alpha-peptides. Three main strategies have been used to design bioactive beta-peptides: direct conversion of alpha-peptide sequences into beta-peptide sequences, placement of side chains to provide desirable distribution of physicochemical properties, and the grafting of proteinaceous side chains critical for bioactivity onto beta-peptide structures. This chapter briefly discusses the various strategies employed to design bioactive beta-peptides, followed by protocols for the synthesis of N-alpha-fluorenylmethyloxycarbonyl (Fmoc)-protected beta3-amino acids from Fmoc-protected alpha-amino acids, and synthesis of beta-peptides by solid phase methods using Fmoc-based chemistry. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 1 | 5% |
| Student > Bachelor | 1 | 5% |
| Unknown | 19 | 90% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 2 | 10% |
| Unknown | 19 | 90% |