| Chapter title |
Impact of Genetic Markers on Treatment of Non-small Cell Lung Cancer.
|
|---|---|
| Chapter number | 6 |
| Book title |
Impact of Genetic Targets on Cancer Therapy
|
| Published in |
Advances in experimental medicine and biology, January 2013
|
| DOI | 10.1007/978-1-4614-6176-0_6 |
| Pubmed ID | |
| Book ISBNs |
978-1-4614-6175-3, 978-1-4614-6176-0
|
| Authors |
Nicholas Lamparella, Amit Barochia, Salah Almokadem, Lamparella, Nicholas, Barochia, Amit, Almokadem, Salah |
| Abstract |
Non-small cell lung cancer represents a group of heterogeneous diseases. The last decade witnessed significant progress in improving our understanding of the biology of non-small cell lung cancer, which led to the identification of several genetic targets. Those genetic targets were utilized to explain clinical phenomena, such as the occurrence of non-small cell lung cancer in never-smokers, to predict response to conventional chemotherapy and biological agents, and to explain and predict resistance to therapy. The progress in the treatment of non-small cell lung cancer in the last few years was based on a new generation of population-enriched clinical trials that utilized genetic targets such as somatic EGFR mutations and ALK-EML4 mutations. In this review we will discuss the available information about the key genetic markers of non-small cell lung cancer and the pivotal clinical trials that validate the use of those genetic markers in non-small cell lung cancer patients. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 14 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 21% |
| Professor > Associate Professor | 3 | 21% |
| Student > Ph. D. Student | 2 | 14% |
| Student > Postgraduate | 2 | 14% |
| Student > Doctoral Student | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 2 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 5 | 36% |
| Biochemistry, Genetics and Molecular Biology | 3 | 21% |
| Agricultural and Biological Sciences | 2 | 14% |
| Unspecified | 1 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
| Other | 1 | 7% |
| Unknown | 1 | 7% |